(6S)-2-nitro-6-{3-[4-trifluoromethoxyphenyl]propoxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine

Base Information

• Chemical Name: (6S)-2-nitro-6-{3-[4-trifluoromethoxyphenyl]propoxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine
• CAS No.: 1333170-20-9
• Molecular Formula: C₁₆H₁₆F₃N₃O₅
• Molecular Weight: 387.315
• Mol file: 1333170-20-9.mol

Synonyms:

Chemical Property of (6S)-2-nitro-6-{3-[4-trifluoromethoxyphenyl]propoxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (6S)-2-nitro-6-{3-[4-trifluoromethoxyphenyl]propoxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine

There total 2 articles about (6S)-2-nitro-6-{3-[4-trifluoromethoxyphenyl]propoxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

(S)‐2‐nitro‐6,7‐dihydro‐5H‐imidazo[2,1‐b][1,3]oxazin‐6‐ol (187235-08-1) + 1-(3-iodopropyl)-4-trifluoromethoxybenzene (1333171-23-5) → (6S)-2-nitro-6-{3-[4-trifluoromethoxyphenyl]propoxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (1333170-20-9)

Guidance literature:

(S)‐2‐nitro‐6,7‐dihydro‐5H‐imidazo[2,1‐b][1,3]oxazin‐6‐ol; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.166667h; Inert atmosphere;

1-(3-iodopropyl)-4-trifluoromethoxybenzene; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 5h; Inert atmosphere;

DOI:10.1021/jm200377r

Reference yield:

3-(4-trifluoromethoxyphenyl)propan-1-ol (1000519-40-3) → (6S)-2-nitro-6-{3-[4-trifluoromethoxyphenyl]propoxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (1333170-20-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 1H-imidazole; chloro-diphenylphosphine / toluene / 0.08 h / 20 °C / Inert atmosphere

1.2: 6 h / 20 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 0 °C / Inert atmosphere

2.2: 5 h / 20 °C / Inert atmosphere

With 1H-imidazole; sodium hydride; chloro-diphenylphosphine; In N,N-dimethyl-formamide; toluene; mineral oil;

DOI:10.1021/jm200377r

upstream raw materials:

(S)‐2‐nitro‐6,7‐dihydro‐5H‐imidazo[2,1‐b][1,3]oxazin‐6‐ol

1-(3-iodopropyl)-4-trifluoromethoxybenzene

3-(4-trifluoromethoxyphenyl)propan-1-ol

Refernces