Technology Process of Cyclobutanecarboxylic acid, 2-methyl-, (1S,2R)-
There total 9 articles about Cyclobutanecarboxylic acid, 2-methyl-, (1S,2R)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sulfuric acid;
In
tetrahydrofuran; water;
for 23h;
Heating;
DOI:10.1021/jo0009550
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 82 percent / NaBH4 / tetrahydrofuran
2: 89 percent / H2 / Pd/C / diethyl ether / 4 h
3: HBr / -78 - 20 °C
4: 0.67 g / NaBH4 / hexamethylphosphoric acid triamide / 3 h / 0 - 20 °C
5: 91 percent / H2SO4 / tetrahydrofuran; H2O / 23 h / Heating
With
sodium tetrahydroborate; sulfuric acid; hydrogen bromide; hydrogen;
palladium on activated charcoal;
In
tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether; water;
1: Reduction / 2: Catalytic hydrogenation / 3: Ring cleavage / 4: Reduction / 5: Hydrolysis;
DOI:10.1021/jo0009550
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 89 percent / H2 / Pd/C / diethyl ether / 4 h
2: HBr / -78 - 20 °C
3: 0.67 g / NaBH4 / hexamethylphosphoric acid triamide / 3 h / 0 - 20 °C
4: 91 percent / H2SO4 / tetrahydrofuran; H2O / 23 h / Heating
With
sodium tetrahydroborate; sulfuric acid; hydrogen bromide; hydrogen;
palladium on activated charcoal;
In
tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether; water;
1: Catalytic hydrogenation / 2: Ring cleavage / 3: Reduction / 4: Hydrolysis;
DOI:10.1021/jo0009550
