Boc-Phe-His-Sta-Leu-(+)-1,2-dipehnylethylamine

Base Information

• Chemical Name: Boc-Phe-His-Sta-Leu-(+)-1,2-dipehnylethylamine
• CAS No.: 87691-40-5
• Molecular Formula: C₄₈H₆₅N₇O₇
• Molecular Weight: 852.087
• Mol file: 87691-40-5.mol

Synonyms:

Chemical Property of Boc-Phe-His-Sta-Leu-(+)-1,2-dipehnylethylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Boc-Phe-His-Sta-Leu-(+)-1,2-dipehnylethylamine

There total 5 articles about Boc-Phe-His-Sta-Leu-(+)-1,2-dipehnylethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-tert-butoxycarbonyl-L-leucine (13139-15-6,53296-34-7) → Boc-Phe-His-Sta-Leu-(+)-1,2-dipehnylethylamine (87691-40-5)

Guidance literature:

Multi-step reaction with 3 steps

1: polystyrene-vinylbenzene resin, dicyclohexylcarbodimimide, 1-hydroxybenzotriazole

2: 0.81 g / hydrazine / methanol / 0.25 h / Ambient temperature

3: 1.) 7 N HCl, isoamyl nitrite / 1.) DMF, THF, -25 deg C, 1 h, 2.) DMF, THF, -20 deg C, 14 h

With hydrogenchloride; polystyrene-vinylbenzene resin; benzotriazol-1-ol; dicyclohexyl-carbodiimide; hydrazine; isopentyl nitrite; In methanol;

DOI:10.1021/jm00393a029

Reference yield:

N-tert-butoxycarbonyl-L-phenylalanine (13734-34-4) → Boc-Phe-His-Sta-Leu-(+)-1,2-dipehnylethylamine (87691-40-5)

Guidance literature:

Multi-step reaction with 3 steps

1: polystyrene-vinylbenzene resin, dicyclohexylcarbodimimide, 1-hydroxybenzotriazole

2: 0.81 g / hydrazine / methanol / 0.25 h / Ambient temperature

3: 1.) 7 N HCl, isoamyl nitrite / 1.) DMF, THF, -25 deg C, 1 h, 2.) DMF, THF, -20 deg C, 14 h

With hydrogenchloride; polystyrene-vinylbenzene resin; benzotriazol-1-ol; dicyclohexyl-carbodiimide; hydrazine; isopentyl nitrite; In methanol;

DOI:10.1021/jm00393a029

Reference yield:

(3S,4S)-4-(tert-butoxycarbonylamino)-3-hydroxy-6-methylheptanoic acid (58521-49-6) → Boc-Phe-His-Sta-Leu-(+)-1,2-dipehnylethylamine (87691-40-5)

Guidance literature:

Multi-step reaction with 3 steps

1: polystyrene-vinylbenzene resin, dicyclohexylcarbodimimide, 1-hydroxybenzotriazole

2: 0.81 g / hydrazine / methanol / 0.25 h / Ambient temperature

3: 1.) 7 N HCl, isoamyl nitrite / 1.) DMF, THF, -25 deg C, 1 h, 2.) DMF, THF, -20 deg C, 14 h

With hydrogenchloride; polystyrene-vinylbenzene resin; benzotriazol-1-ol; dicyclohexyl-carbodiimide; hydrazine; isopentyl nitrite; In methanol;

DOI:10.1021/jm00393a029

upstream raw materials:

(S)-1,2-diphenylethyl amine

(tert-butyloxycarbonyl)-L-phenylalanyl-L-histidyl-(3S,4S)-statyl-L-leucine hydrazide

N-tert-butoxycarbonyl-L-leucine

N-tert-butoxycarbonyl-L-phenylalanine