carbonic acid 4-(3-(3-bromo-propoxy)-4-{1-[(4-chloro-benzenesulfonyl)-(2,5-difluoro-phenyl)-amino]-ethyl}-benzoyl)-benzyl ester 4-nitro-phenyl ester

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Chemical Name:carbonic acid 4-(3-(3-bromo-propoxy)-4-{1-[(4-chloro-benzenesulfonyl)-(2,5-difluoro-phenyl)-amino]-ethyl}-benzoyl)-benzyl ester 4-nitro-phenyl ester
CAS No.:920012-41-5
Molecular Formula:C₃₈H₃₀BrClF₂N₂O₉S
Molecular Weight:844.084
Hs Code.:

carbonic acid 4-(3-(3-bromo-propoxy)-4-{1-[(4-chloro-benzenesulfonyl)-(2,5-difluoro-phenyl)-amino]-ethyl}-benzoyl)-benzyl ester 4-nitro-phenyl ester

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Chemical Property of carbonic acid 4-(3-(3-bromo-propoxy)-4-{1-[(4-chloro-benzenesulfonyl)-(2,5-difluoro-phenyl)-amino]-ethyl}-benzoyl)-benzyl ester 4-nitro-phenyl ester

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Technology Process of carbonic acid 4-(3-(3-bromo-propoxy)-4-{1-[(4-chloro-benzenesulfonyl)-(2,5-difluoro-phenyl)-amino]-ethyl}-benzoyl)-benzyl ester 4-nitro-phenyl ester

There total 13 articles about carbonic acid 4-(3-(3-bromo-propoxy)-4-{1-[(4-chloro-benzenesulfonyl)-(2,5-difluoro-phenyl)-amino]-ethyl}-benzoyl)-benzyl ester 4-nitro-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 909124-64-7
3-hydroxy-4-iodo-N-methoxy-N-methyl-benzamide

: 920012-41-5
carbonic acid 4-(3-(3-bromo-propoxy)-4-{1-[(4-chloro-benzenesulfonyl)-(2,5-difluoro-phenyl)-amino]-ethyl}-benzoyl)-benzyl ester 4-nitro-phenyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: 98 percent / PdCl₂(PPh₃)2; PPh₃; CuI / Et₃N / tetrahydrofuran / 20 °C

2.1: 89 percent / PPh₃; DEAD / toluene / 0 - 20 °C

3.1: 70 percent / formic acid / 60 °C

4.1: 97 percent / NaBH₄ / methanol / 0 °C

5.1: i-PrMgBr / tetrahydrofuran / -20 °C

5.2: 71 percent / tetrahydrofuran / -78 - 0 °C

6.1: 82 percent / PPh₃; DEAD / toluene / 0 - 20 °C

7.1: 95 percent / aq. HF / acetonitrile / 0 °C

8.1: 97 percent / pyridine / acetonitrile; tetrahydrofuran / 20 °C

With pyridine; bis-triphenylphosphine-palladium(II) chloride; sodium tetrahydroborate; copper(l) iodide; formic acid; hydrogen fluoride; isopropylmagnesium bromide; triphenylphosphine; diethylazodicarboxylate; triethylamine; In tetrahydrofuran; methanol; toluene; acetonitrile; 1.1: Sonogashira coupling / 2.1: Mitsunobu reaction / 6.1: Mitsunobu reaction;
DOI:10.1016/j.bmcl.2006.05.091

Reference yield:

: 909124-60-3
3-hydroxy-N-methoxy-N-methyl-4-nitro-benzamide

: 920012-41-5
carbonic acid 4-(3-(3-bromo-propoxy)-4-{1-[(4-chloro-benzenesulfonyl)-(2,5-difluoro-phenyl)-amino]-ethyl}-benzoyl)-benzyl ester 4-nitro-phenyl ester

Guidance literature:: Multi-step reaction with 10 steps

1.1: 99 percent / H₂ / Pd/C / methanol / 20 °C

2.1: NaNO₂; aq. HCl / 0 °C

2.2: 68 percent / KI / 20 °C

3.1: 98 percent / PdCl₂(PPh₃)2; PPh₃; CuI / Et₃N / tetrahydrofuran / 20 °C

4.1: 89 percent / PPh₃; DEAD / toluene / 0 - 20 °C

5.1: 70 percent / formic acid / 60 °C

6.1: 97 percent / NaBH₄ / methanol / 0 °C

7.1: i-PrMgBr / tetrahydrofuran / -20 °C

7.2: 71 percent / tetrahydrofuran / -78 - 0 °C

8.1: 82 percent / PPh₃; DEAD / toluene / 0 - 20 °C

9.1: 95 percent / aq. HF / acetonitrile / 0 °C

10.1: 97 percent / pyridine / acetonitrile; tetrahydrofuran / 20 °C

With pyridine; hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; sodium tetrahydroborate; copper(l) iodide; formic acid; hydrogen fluoride; hydrogen; isopropylmagnesium bromide; triphenylphosphine; sodium nitrite; diethylazodicarboxylate; palladium on activated charcoal; triethylamine; In tetrahydrofuran; methanol; toluene; acetonitrile; 3.1: Sonogashira coupling / 4.1: Mitsunobu reaction / 8.1: Mitsunobu reaction;
DOI:10.1016/j.bmcl.2006.05.091

Reference yield:

: 909124-62-5
4-amino-3-hydroxy-N-methoxy-N-methyl-benzamide

: 920012-41-5
carbonic acid 4-(3-(3-bromo-propoxy)-4-{1-[(4-chloro-benzenesulfonyl)-(2,5-difluoro-phenyl)-amino]-ethyl}-benzoyl)-benzyl ester 4-nitro-phenyl ester

Guidance literature:: Multi-step reaction with 9 steps

1.1: NaNO₂; aq. HCl / 0 °C

1.2: 68 percent / KI / 20 °C

2.1: 98 percent / PdCl₂(PPh₃)2; PPh₃; CuI / Et₃N / tetrahydrofuran / 20 °C

3.1: 89 percent / PPh₃; DEAD / toluene / 0 - 20 °C

4.1: 70 percent / formic acid / 60 °C

5.1: 97 percent / NaBH₄ / methanol / 0 °C

6.1: i-PrMgBr / tetrahydrofuran / -20 °C

6.2: 71 percent / tetrahydrofuran / -78 - 0 °C

7.1: 82 percent / PPh₃; DEAD / toluene / 0 - 20 °C

8.1: 95 percent / aq. HF / acetonitrile / 0 °C

9.1: 97 percent / pyridine / acetonitrile; tetrahydrofuran / 20 °C

With pyridine; hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; sodium tetrahydroborate; copper(l) iodide; formic acid; hydrogen fluoride; isopropylmagnesium bromide; triphenylphosphine; sodium nitrite; diethylazodicarboxylate; triethylamine; In tetrahydrofuran; methanol; toluene; acetonitrile; 2.1: Sonogashira coupling / 3.1: Mitsunobu reaction / 7.1: Mitsunobu reaction;
DOI:10.1016/j.bmcl.2006.05.091