ethyl (E)-2,3-dihydro-5-(o-fluorobenzoyl)-6-hydroxy-7-methoxybenzofuran-2-carboxylate oxime

Base Information

Chemical Name:ethyl (E)-2,3-dihydro-5-(o-fluorobenzoyl)-6-hydroxy-7-methoxybenzofuran-2-carboxylate oxime
CAS No.:90246-91-6
Molecular Formula:C₁₉H₁₈FNO₆
Molecular Weight:375.353
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ethyl (E)-2,3-dihydro-5-(o-fluorobenzoyl)-6-hydroxy-7-methoxybenzofuran-2-carboxylate oxime

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Technology Process of ethyl (E)-2,3-dihydro-5-(o-fluorobenzoyl)-6-hydroxy-7-methoxybenzofuran-2-carboxylate oxime

There total 6 articles about ethyl (E)-2,3-dihydro-5-(o-fluorobenzoyl)-6-hydroxy-7-methoxybenzofuran-2-carboxylate oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.0%

: 90246-82-5
ethyl 2,3-dihydro-5-(o-fluorobenzoyl)-6-hydroxy-7-methoxybenzofuran-2-carboxylate

: 90246-91-6
ethyl (E)-2,3-dihydro-5-(o-fluorobenzoyl)-6-hydroxy-7-methoxybenzofuran-2-carboxylate oxime

Guidance literature:: With pyridine; hydroxylamine hydrochloride; for 4h; Heating;
DOI:10.1021/jm00374a014

Reference yield:

: 19283-70-6
3,4-dimethoxysalicylaldehyde

: 90246-91-6
ethyl (E)-2,3-dihydro-5-(o-fluorobenzoyl)-6-hydroxy-7-methoxybenzofuran-2-carboxylate oxime

Guidance literature:: Multi-step reaction with 6 steps

1: K₂CO₃ / butan-2-one / 4 h / Heating

2: ethanolic KOH

3: aq. NaOH, 5percent sodium amalgam / 5 h

4: H₂SO₄ / Ambient temperature

5: 32 percent / AlCl₃ / 1,2-dichloro-ethane / 3.75 h / 5 - 20 °C

6: 18 percent / NH₂OH*HCl, pyridine / 4 h / Heating

With pyridine; potassium hydroxide; sodium hydroxide; sodium amalgam; aluminium trichloride; sulfuric acid; hydroxylamine hydrochloride; potassium carbonate; In 1,2-dichloro-ethane; butanone;
DOI:10.1021/jm00374a014

Reference yield:

: 76313-60-5
6,7-dimethoxybenzofuran-2-carboxylic acid

: 90246-91-6
ethyl (E)-2,3-dihydro-5-(o-fluorobenzoyl)-6-hydroxy-7-methoxybenzofuran-2-carboxylate oxime

Guidance literature:: Multi-step reaction with 4 steps

1: aq. NaOH, 5percent sodium amalgam / 5 h

2: H₂SO₄ / Ambient temperature

3: 32 percent / AlCl₃ / 1,2-dichloro-ethane / 3.75 h / 5 - 20 °C

4: 18 percent / NH₂OH*HCl, pyridine / 4 h / Heating

With pyridine; sodium hydroxide; sodium amalgam; aluminium trichloride; sulfuric acid; hydroxylamine hydrochloride; In 1,2-dichloro-ethane;
DOI:10.1021/jm00374a014