5,5-dimethyl-1,2,4-triphenyl-1,4,5,6-tetrahydropyrimidine

Base Information

Chemical Name:5,5-dimethyl-1,2,4-triphenyl-1,4,5,6-tetrahydropyrimidine
CAS No.:1416437-73-4
Molecular Formula:C₂₄H₂₄N₂
Molecular Weight:340.468
Hs Code.:

Synonyms:

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Chemical Property of 5,5-dimethyl-1,2,4-triphenyl-1,4,5,6-tetrahydropyrimidine

Chemical Property:

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Safty Information:

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Technology Process of 5,5-dimethyl-1,2,4-triphenyl-1,4,5,6-tetrahydropyrimidine

There total 3 articles about 5,5-dimethyl-1,2,4-triphenyl-1,4,5,6-tetrahydropyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1416437-85-8
N-(2,2-dimethyl-3-phenylpropyl)aniline

: 1416437-73-4
5,5-dimethyl-1,2,4-triphenyl-1,4,5,6-tetrahydropyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: trimethylaluminum / toluene / 1 h / 0 - 20 °C

1.2: 20 h / 100 °C

2.1: copper diacetate; potassium phosphate; [bis(acetoxy)iodo]benzene / N,N-dimethyl-formamide / 23 h / 60 °C / Inert atmosphere

With potassium phosphate; [bis(acetoxy)iodo]benzene; trimethylaluminum; copper diacetate; In N,N-dimethyl-formamide; toluene;
DOI:10.1021/ol303302r

Reference yield:

: 35863-45-7
2,2-dimethyl-3-phenylpropanenitrile

: 1416437-73-4
5,5-dimethyl-1,2,4-triphenyl-1,4,5,6-tetrahydropyrimidine

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium aluminium tetrahydride / diethyl ether / 20 h / 20 °C / Inert atmosphere

2.1: copper(l) iodide; L-proline; potassium carbonate / dimethyl sulfoxide / 17 h / 80 °C / Inert atmosphere

3.1: trimethylaluminum / toluene / 1 h / 0 - 20 °C

3.2: 20 h / 100 °C

4.1: copper diacetate; potassium phosphate; [bis(acetoxy)iodo]benzene / N,N-dimethyl-formamide / 23 h / 60 °C / Inert atmosphere

With potassium phosphate; copper(l) iodide; lithium aluminium tetrahydride; [bis(acetoxy)iodo]benzene; trimethylaluminum; copper diacetate; potassium carbonate; L-proline; In diethyl ether; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;
DOI:10.1021/ol303302r

Reference yield:

: 95141-79-0
2,2-dimethyl-3-phenylpropan-1-amine

: 1416437-73-4
5,5-dimethyl-1,2,4-triphenyl-1,4,5,6-tetrahydropyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: copper(l) iodide; L-proline; potassium carbonate / dimethyl sulfoxide / 17 h / 80 °C / Inert atmosphere

2.1: trimethylaluminum / toluene / 1 h / 0 - 20 °C

2.2: 20 h / 100 °C

3.1: copper diacetate; potassium phosphate; [bis(acetoxy)iodo]benzene / N,N-dimethyl-formamide / 23 h / 60 °C / Inert atmosphere

With potassium phosphate; copper(l) iodide; [bis(acetoxy)iodo]benzene; trimethylaluminum; copper diacetate; potassium carbonate; L-proline; In dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;
DOI:10.1021/ol303302r