(R)-2-(6-((2-(5,5-dimethylcyclopent-1-en-1-yl)-2'-fluoro-5'-methoxy-[1,1'-biphenyl]-4-yl)methoxy)-2,3-dihydro-1H-inden-1-yl)acetic acid

Base Information

• Chemical Name: (R)-2-(6-((2-(5,5-dimethylcyclopent-1-en-1-yl)-2'-fluoro-5'-methoxy-[1,1'-biphenyl]-4-yl)methoxy)-2,3-dihydro-1H-inden-1-yl)acetic acid
• CAS No.: 1187198-00-0
• Molecular Formula: C₃₂H₃₃FO₄
• Molecular Weight: 500.61
• Mol file: 1187198-00-0.mol

Synonyms:

Chemical Property of (R)-2-(6-((2-(5,5-dimethylcyclopent-1-en-1-yl)-2'-fluoro-5'-methoxy-[1,1'-biphenyl]-4-yl)methoxy)-2,3-dihydro-1H-inden-1-yl)acetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-2-(6-((2-(5,5-dimethylcyclopent-1-en-1-yl)-2'-fluoro-5'-methoxy-[1,1'-biphenyl]-4-yl)methoxy)-2,3-dihydro-1H-inden-1-yl)acetic acid

There total 6 articles about (R)-2-(6-((2-(5,5-dimethylcyclopent-1-en-1-yl)-2'-fluoro-5'-methoxy-[1,1'-biphenyl]-4-yl)methoxy)-2,3-dihydro-1H-inden-1-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C33H35FO4 (1187197-98-3) → (R)-2-(6-((2-(5,5-dimethylcyclopent-1-en-1-yl)-2'-fluoro-5'-methoxy-[1,1'-biphenyl]-4-yl)methoxy)-2,3-dihydro-1H-inden-1-yl)acetic acid (1187198-00-0)

Guidance literature:

With water; lithium hydroxide; In tetrahydrofuran; ethanol; at 50 ℃; for 15h; Inert atmosphere;

DOI:10.1021/ml300427u

Reference yield:

6-(benzyloxy)-2,3-dihydro-1H-inden-1-one (25083-80-1) → (R)-2-(6-((2-(5,5-dimethylcyclopent-1-en-1-yl)-2'-fluoro-5'-methoxy-[1,1'-biphenyl]-4-yl)methoxy)-2,3-dihydro-1H-inden-1-yl)acetic acid (1187198-00-0)

Guidance literature:

Multi-step reaction with 5 steps

1.1: lithium hexamethyldisilazane / hexane; tetrahydrofuran / 0.37 h / -78 °C / Inert atmosphere

1.2: -78 - 20 °C / Inert atmosphere

2.1: hydrogen; palladium 10% on activated carbon / methanol / 24 h / Inert atmosphere

3.1: OJ column / hexane; isopropyl alcohol / Resolution of racemate; Inert atmosphere

4.1: caesium carbonate / dimethyl sulfoxide / 16 h / 23 °C / Inert atmosphere

5.1: water; lithium hydroxide / tetrahydrofuran; ethanol / 15 h / 50 °C / Inert atmosphere

With palladium 10% on activated carbon; water; hydrogen; caesium carbonate; lithium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; ethanol; hexane; dimethyl sulfoxide; isopropyl alcohol;

DOI:10.1021/ml300427u

Reference yield:

(E)-methyl 2-(6-(benzyloxy)-2,3-dihydroinden-1-ylidene)acetate (1187197-90-5) → (R)-2-(6-((2-(5,5-dimethylcyclopent-1-en-1-yl)-2'-fluoro-5'-methoxy-[1,1'-biphenyl]-4-yl)methoxy)-2,3-dihydro-1H-inden-1-yl)acetic acid (1187198-00-0)

Guidance literature:

Multi-step reaction with 4 steps

1: hydrogen; palladium 10% on activated carbon / methanol / 24 h / Inert atmosphere

2: OJ column / hexane; isopropyl alcohol / Resolution of racemate; Inert atmosphere

3: caesium carbonate / dimethyl sulfoxide / 16 h / 23 °C / Inert atmosphere

4: water; lithium hydroxide / tetrahydrofuran; ethanol / 15 h / 50 °C / Inert atmosphere

With palladium 10% on activated carbon; water; hydrogen; caesium carbonate; lithium hydroxide; In tetrahydrofuran; methanol; ethanol; hexane; dimethyl sulfoxide; isopropyl alcohol;

DOI:10.1021/ml300427u

upstream raw materials:

C₃₃H₃₅FO₄

6-(benzyloxy)-2,3-dihydro-1H-inden-1-one

(E)-methyl 2-(6-(benzyloxy)-2,3-dihydroinden-1-ylidene)acetate

6-hydroxy-1-indanone