(1S,2R,3R)-1-[(R)-4-(4-cyclopropylphenyl)-3-methylpiperazine-1-sulfonylamino]-2-methyl-3-phenylcyclopropane-1-carboxylic acid hydrochloride

Base Information

Chemical Name:(1S,2R,3R)-1-[(R)-4-(4-cyclopropylphenyl)-3-methylpiperazine-1-sulfonylamino]-2-methyl-3-phenylcyclopropane-1-carboxylic acid hydrochloride
CAS No.:1288977-20-7
Molecular Formula:C₂₅H₃₁N₃O₄S*ClH
Molecular Weight:506.066
Hs Code.:

(1S,2R,3R)-1-[(R)-4-(4-cyclopropylphenyl)-3-methylpiperazine-1-sulfonylamino]-2-methyl-3-phenylcyclopropane-1-carboxylic acid hydrochloride

Synonyms:

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Chemical Property of (1S,2R,3R)-1-[(R)-4-(4-cyclopropylphenyl)-3-methylpiperazine-1-sulfonylamino]-2-methyl-3-phenylcyclopropane-1-carboxylic acid hydrochloride

Chemical Property:

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Technology Process of (1S,2R,3R)-1-[(R)-4-(4-cyclopropylphenyl)-3-methylpiperazine-1-sulfonylamino]-2-methyl-3-phenylcyclopropane-1-carboxylic acid hydrochloride

There total 7 articles about (1S,2R,3R)-1-[(R)-4-(4-cyclopropylphenyl)-3-methylpiperazine-1-sulfonylamino]-2-methyl-3-phenylcyclopropane-1-carboxylic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₉H₃₉N₃O₄S

: 1288977-20-7
(1S,2R,3R)-1-[(R)-4-(4-cyclopropylphenyl)-3-methylpiperazine-1-sulfonylamino]-2-methyl-3-phenylcyclopropane-1-carboxylic acid hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 12h;
DOI:10.1021/jm101609j

Reference yield:

: 108-86-1,52753-63-6
bromobenzene

: 1288977-20-7
(1S,2R,3R)-1-[(R)-4-(4-cyclopropylphenyl)-3-methylpiperazine-1-sulfonylamino]-2-methyl-3-phenylcyclopropane-1-carboxylic acid hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1: tri-tert-butyl phosphine; palladium diacetate; sodium t-butanolate / toluene / 12 h / 110 °C / Inert atmosphere

2: tetra-N-butylammonium tribromide / chloroform / 0.5 h / 0 - 20 °C

3: potassium phosphate; palladium diacetate; tricyclohexylphosphine / water; toluene / 4 h / 110 °C

4: hydrogenchloride / 1,4-dioxane / 12 h / 20 °C

5: 4-methyl-morpholine / 1,4-dioxane / 100 °C / Inert atmosphere

6: hydrogenchloride / 1,4-dioxane / 12 h / 20 °C

With 4-methyl-morpholine; hydrogenchloride; potassium phosphate; tri-tert-butyl phosphine; palladium diacetate; tetra-N-butylammonium tribromide; sodium t-butanolate; tricyclohexylphosphine; In 1,4-dioxane; chloroform; water; toluene;
DOI:10.1021/jm101609j

Reference yield:

: 1089686-77-0
(R)-1-(4-bromophenyl)-4-tert-butoxycarbonyl-2-methylpiperazine

: 1288977-20-7
(1S,2R,3R)-1-[(R)-4-(4-cyclopropylphenyl)-3-methylpiperazine-1-sulfonylamino]-2-methyl-3-phenylcyclopropane-1-carboxylic acid hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: potassium phosphate; palladium diacetate; tricyclohexylphosphine / water; toluene / 4 h / 110 °C

2: hydrogenchloride / 1,4-dioxane / 12 h / 20 °C

3: 4-methyl-morpholine / 1,4-dioxane / 100 °C / Inert atmosphere

4: hydrogenchloride / 1,4-dioxane / 12 h / 20 °C

With 4-methyl-morpholine; hydrogenchloride; potassium phosphate; palladium diacetate; tricyclohexylphosphine; In 1,4-dioxane; water; toluene;
DOI:10.1021/jm101609j