C₁₂H₁₀F₂N₂O₆

Base Information

• Chemical Name: C₁₂H₁₀F₂N₂O₆
• CAS No.: 1256346-79-8
• Molecular Formula: C₁₂H₁₀F₂N₂O₆
• Molecular Weight: 316.218
• Mol file: 1256346-79-8.mol

Synonyms:

Chemical Property of C₁₂H₁₀F₂N₂O₆

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₂H₁₀F₂N₂O₆

There total 1 articles about C₁₂H₁₀F₂N₂O₆ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,6-difluorobenzene diazonium tetrafluoroborate + ascorbic acid (50-81-7,98966-42-8) → C12H10F2N2O6 (1256346-79-8)

Guidance literature:

In water; acetonitrile; at 20 ℃; for 0.5h;

DOI:10.1021/op100205s

Reference yield:

C12H10F2N2O6 (1256346-79-8) → C9H8F2N2O3

Guidance literature:

With methanesulfonic acid; In methanol; water; acetonitrile; at 20 - 60 ℃;

DOI:10.1021/op100205s

Reference yield:

C12H10F2N2O6 (1256346-79-8) → N-cyclopropyl-3-[1-(2,6-difluorophenyl)-7-methyl-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridin-5-yl]-4-methylbenzamide (1080572-01-5)

Guidance literature:

Multi-step reaction with 7 steps

1.1: methanesulfonic acid / methanol; water; acetonitrile / 20 - 60 °C

2.1: sodium hydroxide / methanol; water; acetonitrile / 0.33 h / 20 °C / pH 6

2.2: 80 °C

3.1: hydrogen / water; acetic acid / 6.5 h / 1535.79 Torr / Autoclave; Large scale reaction

4.1: piperidine / ethanol / 7 h / Reflux; Large scale reaction

4.2: Reflux

5.1: N-Bromosuccinimide; lithium acetate / tetrahydrofuran; water / 6 h / 20 - 50 °C / Large scale reaction

6.1: lithium tert-butoxide / tetrahydrofuran / 20 - 30 °C / Large scale reaction

6.2: 18 h / 40 °C

7.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate / 1,2-dimethoxyethane; water / Reflux

With piperidine; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; methanesulfonic acid; lithium acetate; hydrogen; sodium hydrogencarbonate; sodium hydroxide; lithium tert-butoxide; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; ethanol; water; acetic acid; acetonitrile; 4.1: Knoevenagel condensation / 5.1: Hunsdiecker reaction / 7.1: Suzuki coupling;

DOI:10.1021/op100205s

upstream raw materials:

ascorbic acid

Downstream raw materials:

5-amino-1-(2,6-difluorophenyl)-1H-pyrazole-4-carbonitrile

5-amino-1-(2,6-difluorophenyl)-1H-pyrazole-4-carbaldehyde

ethyl 1-(2,6-difluorophenyl)-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridine-5-carboxylate

5-bromo-1-(2,6-difluorophenyl)-1H-pyrazolo[3,4-b]pyridin-6(7H)-one