[(1R,6S,10S)-1-(3-Methoxy-phenyl)-bicyclo[4.3.1]dec-10-yl]-methyl-phenethyl-amine; hydrobromide

Base Information

• Chemical Name: [(1R,6S,10S)-1-(3-Methoxy-phenyl)-bicyclo[4.3.1]dec-10-yl]-methyl-phenethyl-amine; hydrobromide
• CAS No.: 75210-06-9
• Molecular Formula: BrH*C₂₆H₃₅NO
• Molecular Weight: 458.482

Synonyms:

Chemical Property of [(1R,6S,10S)-1-(3-Methoxy-phenyl)-bicyclo[4.3.1]dec-10-yl]-methyl-phenethyl-amine; hydrobromide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [(1R,6S,10S)-1-(3-Methoxy-phenyl)-bicyclo[4.3.1]dec-10-yl]-methyl-phenethyl-amine; hydrobromide

There total 15 articles about [(1R,6S,10S)-1-(3-Methoxy-phenyl)-bicyclo[4.3.1]dec-10-yl]-methyl-phenethyl-amine; hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-methoxyphenyl bromide (2398-37-0) → [(1R,6S,10S)-1-(3-Methoxy-phenyl)-bicyclo[4.3.1]dec-10-yl]-methyl-phenethyl-amine; hydrobromide (75210-06-9)

Guidance literature:

Multi-step reaction with 15 steps

1: 1.) Mg / 1.) THF, 2.) THF, room temp., 30 min, 50-55 deg C, 1 h

2: oxalic acid / toluene / 16 h / Heating

3: 1.) NaBH₄, BF₃*Et₂O, 2.) 10percent NaOH, 30percent H₂O₂ / 1.) THF, room temp., 15 h, 2.) THF, H₂O, room temp., 1 h

4: 33.6 percent / Na₂Cr₂O₇*2H₂O, conc. H₂SO₄ / diethyl ether; H₂O / 2 h / 5 - 13 °C

5: 75.8 percent / TiCl₄ / benzene / 1.) room temp., overnight, 2.) 75-80 deg C, 8 h

6: 78 percent / benzene / 20 h / Heating

7: 90.3 percent / NH₂OH*HCl, NaOAc / dimethylformamide / Ambient temperature

8: 81.9 percent / LiAlH₄ / tetrahydrofuran; dioxane / Heating

9: 73.3 percent / 5percent NaHCO₃ / CH₂Cl₂ / 4 h / Ambient temperature

10: 80.2 percent / pyridine / 4 h / Ambient temperature

11: 44.3 percent / NaI, Zn / 1,2-dimethoxy-ethane / 76 h / Heating

12: 97.7 percent / H₂ / 10percent Pd-C / ethanol / 7.5 h / 70 - 90 °C / 47808 Torr

13: LiAlH₄ / diethyl ether / 8 h / Heating

14: K₂CO₃ / tetrahydrofuran; H₂O / Ambient temperature

15: 1.) NaBH₄, BF₃*Et₂O, 2.) 23percent HCl, 3.) HBr / 1.) THF, room temp., 2.) EtOH, Et₂O, room temp.

With hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; lithium aluminium tetrahydride; sodium dichromate; sulfuric acid; boron trifluoride diethyl etherate; hydroxylamine hydrochloride; hydrogen bromide; hydrogen; dihydrogen peroxide; sodium acetate; oxalic acid; titanium tetrachloride; sodium hydrogencarbonate; potassium carbonate; magnesium; sodium iodide; zinc; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; pyridine; 1,2-dimethoxyethane; diethyl ether; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; benzene;

DOI:10.1248/cpb.28.1022

Reference yield:

1-(m-methoxyphenyl)cycloheptanol (2082-28-2) → [(1R,6S,10S)-1-(3-Methoxy-phenyl)-bicyclo[4.3.1]dec-10-yl]-methyl-phenethyl-amine; hydrobromide (75210-06-9)

Guidance literature:

Multi-step reaction with 14 steps

1: oxalic acid / toluene / 16 h / Heating

2: 1.) NaBH₄, BF₃*Et₂O, 2.) 10percent NaOH, 30percent H₂O₂ / 1.) THF, room temp., 15 h, 2.) THF, H₂O, room temp., 1 h

3: 33.6 percent / Na₂Cr₂O₇*2H₂O, conc. H₂SO₄ / diethyl ether; H₂O / 2 h / 5 - 13 °C

4: 75.8 percent / TiCl₄ / benzene / 1.) room temp., overnight, 2.) 75-80 deg C, 8 h

5: 78 percent / benzene / 20 h / Heating

6: 90.3 percent / NH₂OH*HCl, NaOAc / dimethylformamide / Ambient temperature

7: 81.9 percent / LiAlH₄ / tetrahydrofuran; dioxane / Heating

8: 73.3 percent / 5percent NaHCO₃ / CH₂Cl₂ / 4 h / Ambient temperature

9: 80.2 percent / pyridine / 4 h / Ambient temperature

10: 44.3 percent / NaI, Zn / 1,2-dimethoxy-ethane / 76 h / Heating

11: 97.7 percent / H₂ / 10percent Pd-C / ethanol / 7.5 h / 70 - 90 °C / 47808 Torr

12: LiAlH₄ / diethyl ether / 8 h / Heating

13: K₂CO₃ / tetrahydrofuran; H₂O / Ambient temperature

14: 1.) NaBH₄, BF₃*Et₂O, 2.) 23percent HCl, 3.) HBr / 1.) THF, room temp., 2.) EtOH, Et₂O, room temp.

With hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; lithium aluminium tetrahydride; sodium dichromate; sulfuric acid; boron trifluoride diethyl etherate; hydroxylamine hydrochloride; hydrogen bromide; hydrogen; dihydrogen peroxide; sodium acetate; oxalic acid; titanium tetrachloride; sodium hydrogencarbonate; potassium carbonate; sodium iodide; zinc; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; pyridine; 1,2-dimethoxyethane; diethyl ether; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; benzene;

DOI:10.1248/cpb.28.1022

Reference yield:

2-(m-methoxyphenyl)-cycloheptanone (35027-80-6) → [(1R,6S,10S)-1-(3-Methoxy-phenyl)-bicyclo[4.3.1]dec-10-yl]-methyl-phenethyl-amine; hydrobromide (75210-06-9)

Guidance literature:

Multi-step reaction with 11 steps

1: 75.8 percent / TiCl₄ / benzene / 1.) room temp., overnight, 2.) 75-80 deg C, 8 h

2: 78 percent / benzene / 20 h / Heating

3: 90.3 percent / NH₂OH*HCl, NaOAc / dimethylformamide / Ambient temperature

4: 81.9 percent / LiAlH₄ / tetrahydrofuran; dioxane / Heating

5: 73.3 percent / 5percent NaHCO₃ / CH₂Cl₂ / 4 h / Ambient temperature

6: 80.2 percent / pyridine / 4 h / Ambient temperature

7: 44.3 percent / NaI, Zn / 1,2-dimethoxy-ethane / 76 h / Heating

8: 97.7 percent / H₂ / 10percent Pd-C / ethanol / 7.5 h / 70 - 90 °C / 47808 Torr

9: LiAlH₄ / diethyl ether / 8 h / Heating

10: K₂CO₃ / tetrahydrofuran; H₂O / Ambient temperature

11: 1.) NaBH₄, BF₃*Et₂O, 2.) 23percent HCl, 3.) HBr / 1.) THF, room temp., 2.) EtOH, Et₂O, room temp.

With hydrogenchloride; sodium tetrahydroborate; lithium aluminium tetrahydride; boron trifluoride diethyl etherate; hydroxylamine hydrochloride; hydrogen bromide; hydrogen; sodium acetate; titanium tetrachloride; sodium hydrogencarbonate; potassium carbonate; sodium iodide; zinc; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; pyridine; 1,2-dimethoxyethane; diethyl ether; ethanol; dichloromethane; water; N,N-dimethyl-formamide; benzene;

DOI:10.1248/cpb.28.1022

upstream raw materials:

3-methoxyphenyl bromide

1-(m-methoxyphenyl)cycloheptanol

2-(m-methoxyphenyl)-cycloheptanone

(E)-1-(3-methoxyphenyl)cyclohept-1-en

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 75210-06-9 [(1R,6S,10S)-1-(3-Methoxy-phenyl)-bicyclo[4.3.1]dec-10-yl]-methyl-phenethyl-amine; hydrobromide

Send

Send

Metric Ton KG G Pound L ML

Send

Send