5-(2-Benzoyloxymethyl-4-methoxy)phenyl-2(5H)-furanone

Base Information

• Chemical Name: 5-(2-Benzoyloxymethyl-4-methoxy)phenyl-2(5H)-furanone
• CAS No.: 87221-55-4
• Molecular Formula: C₁₉H₁₆O₅
• Molecular Weight: 324.333
• Mol file: 87221-55-4.mol

Synonyms:

Chemical Property of 5-(2-Benzoyloxymethyl-4-methoxy)phenyl-2(5H)-furanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(2-Benzoyloxymethyl-4-methoxy)phenyl-2(5H)-furanone

There total 7 articles about 5-(2-Benzoyloxymethyl-4-methoxy)phenyl-2(5H)-furanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

γ-(2-Benzoyloxymethyl-4-methoxy)phenyl-α-phenylseleno-γ-butyrolactone (87221-54-3) → 5-(2-Benzoyloxymethyl-4-methoxy)phenyl-2(5H)-furanone (87221-55-4)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; 1) 0 deg C 2) 25 deg C;

Reference yield:

4-(4-methoxy-2-methylphenyl)-4-oxo-but-1-oic acid (67405-48-5) → 5-(2-Benzoyloxymethyl-4-methoxy)phenyl-2(5H)-furanone (87221-55-4)

Guidance literature:

Multi-step reaction with 6 steps

1: 1) KOH, N₂H₄*H₂O 2) conc.H₂SO₄ / 1) diethylene glycol, reflux

2: 1) NBS, benzoyl peroxide 2) AcOH, Ac₂O / 1) CCl₄, 1h, reflux, irradiation 2) 1.5h, 115-120 deg C

3: 32 percent / NaOH / ethanol; H₂O / 20 h / 30 °C

4: 74.5 percent / pyridine

5: 53 percent / lithium diisopropylamide / tetrahydrofuran / 1) -78 deg C 2) -40 deg C

6: 32 percent / m-chloroperbenzoic acid / tetrahydrofuran / 1) 0 deg C 2) 25 deg C

With pyridine; potassium hydroxide; sodium hydroxide; N-Bromosuccinimide; Perbenzoic acid; sulfuric acid; acetic anhydride; hydrazine hydrate; acetic acid; 3-chloro-benzenecarboperoxoic acid; lithium diisopropyl amide; In tetrahydrofuran; ethanol; water;

Reference yield:

4-(4-Methoxy-2-methyl-phenyl)-butyric acid methyl ester (73115-92-1) → 5-(2-Benzoyloxymethyl-4-methoxy)phenyl-2(5H)-furanone (87221-55-4)

Guidance literature:

Multi-step reaction with 5 steps

1: 1) NBS, benzoyl peroxide 2) AcOH, Ac₂O / 1) CCl₄, 1h, reflux, irradiation 2) 1.5h, 115-120 deg C

2: 32 percent / NaOH / ethanol; H₂O / 20 h / 30 °C

3: 74.5 percent / pyridine

4: 53 percent / lithium diisopropylamide / tetrahydrofuran / 1) -78 deg C 2) -40 deg C

5: 32 percent / m-chloroperbenzoic acid / tetrahydrofuran / 1) 0 deg C 2) 25 deg C

With pyridine; sodium hydroxide; N-Bromosuccinimide; Perbenzoic acid; acetic anhydride; acetic acid; 3-chloro-benzenecarboperoxoic acid; lithium diisopropyl amide; In tetrahydrofuran; ethanol; water;

upstream raw materials:

γ-(2-Benzoyloxymethyl-4-methoxy)phenyl-α-phenylseleno-γ-butyrolactone

4-(4-methoxy-2-methylphenyl)-4-oxo-but-1-oic acid

4-(4-Methoxy-2-methyl-phenyl)-butyric acid methyl ester

γ-(2-Hydroxymethyl-4-methoxy)phenyl-γ-butyrolactone