(S)-2-{(R)-2-((S)-2-Acetylamino-3-phenyl-propionylamino)-3-[4-(tert-butoxycarbonylamino-methyl)-5-methoxymethoxy-6-methyl-pyridin-3-ylmethylsulfanyl]-propionylamino}-propionic acid methyl ester

Base Information

Chemical Name:(S)-2-{(R)-2-((S)-2-Acetylamino-3-phenyl-propionylamino)-3-[4-(tert-butoxycarbonylamino-methyl)-5-methoxymethoxy-6-methyl-pyridin-3-ylmethylsulfanyl]-propionylamino}-propionic acid methyl ester
CAS No.:849771-01-3
Molecular Formula:C₃₃H₄₇N₅O₉S
Molecular Weight:689.83
Hs Code.:

(S)-2-{(R)-2-((S)-2-Acetylamino-3-phenyl-propionylamino)-3-[4-(tert-butoxycarbonylamino-methyl)-5-methoxymethoxy-6-methyl-pyridin-3-ylmethylsulfanyl]-propionylamino}-propionic acid methyl ester

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Chemical Property of (S)-2-{(R)-2-((S)-2-Acetylamino-3-phenyl-propionylamino)-3-[4-(tert-butoxycarbonylamino-methyl)-5-methoxymethoxy-6-methyl-pyridin-3-ylmethylsulfanyl]-propionylamino}-propionic acid methyl ester

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Technology Process of (S)-2-{(R)-2-((S)-2-Acetylamino-3-phenyl-propionylamino)-3-[4-(tert-butoxycarbonylamino-methyl)-5-methoxymethoxy-6-methyl-pyridin-3-ylmethylsulfanyl]-propionylamino}-propionic acid methyl ester

There total 11 articles about (S)-2-{(R)-2-((S)-2-Acetylamino-3-phenyl-propionylamino)-3-[4-(tert-butoxycarbonylamino-methyl)-5-methoxymethoxy-6-methyl-pyridin-3-ylmethylsulfanyl]-propionylamino}-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 10065-72-2
L-Alanine methyl ester

: 849771-00-2
(R)-2-((S)-2-Acetylamino-3-phenyl-propionylamino)-3-[4-(tert-butoxycarbonylamino-methyl)-5-methoxymethoxy-6-methyl-pyridin-3-ylmethylsulfanyl]-propionic acid

: 849771-01-3
(S)-2-{(R)-2-((S)-2-Acetylamino-3-phenyl-propionylamino)-3-[4-(tert-butoxycarbonylamino-methyl)-5-methoxymethoxy-6-methyl-pyridin-3-ylmethylsulfanyl]-propionylamino}-propionic acid methyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate;
DOI:10.1016/j.bmcl.2005.01.021

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 849771-01-3
(S)-2-{(R)-2-((S)-2-Acetylamino-3-phenyl-propionylamino)-3-[4-(tert-butoxycarbonylamino-methyl)-5-methoxymethoxy-6-methyl-pyridin-3-ylmethylsulfanyl]-propionylamino}-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 90 percent / Et₃N

2: 95 percent / imidazole

3: 75 percent / NaH

4: 86 percent / TBAF

5: 100 percent / Et₃N

6: 87 percent / NaH

7: 95 percent / HATU; i-Pr₂NEt

8: 70 percent / LiOH / tetrahydrofuran

9: 82 percent / HATU; i-Pr₂NEt

With 1H-imidazole; lithium hydroxide; tetrabutyl ammonium fluoride; sodium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran;
DOI:10.1016/j.bmcl.2005.01.021

Reference yield:

: 2018-61-3
(S)-2-acetylamino-3-phenylpropanoic acid

: 849771-01-3
(S)-2-{(R)-2-((S)-2-Acetylamino-3-phenyl-propionylamino)-3-[4-(tert-butoxycarbonylamino-methyl)-5-methoxymethoxy-6-methyl-pyridin-3-ylmethylsulfanyl]-propionylamino}-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / HATU; i-Pr₂NEt

2: 70 percent / LiOH / tetrahydrofuran

3: 82 percent / HATU; i-Pr₂NEt

With lithium hydroxide; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran;
DOI:10.1016/j.bmcl.2005.01.021