25-hydroxy-26,27-dimethylvitamin D₃

Base Information

Chemical Name:25-hydroxy-26,27-dimethylvitamin D₃
CAS No.:106372-47-8
Molecular Formula:C₂₉H₄₈O₂
Molecular Weight:428.699
Hs Code.:

25-hydroxy-26,27-dimethylvitamin D<sub>3</sub>

Synonyms:

Suppliers and Price of 25-hydroxy-26,27-dimethylvitamin D₃

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 25-hydroxy-26,27-dimethylvitamin D₃

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of 25-hydroxy-26,27-dimethylvitamin D₃

There total 11 articles about 25-hydroxy-26,27-dimethylvitamin D₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 66414-43-5
3β-(tetrahydro-2H-pyran-2-yloxy)chol-5-en-24-ol

: 106372-47-8
25-hydroxy-26,27-dimethylvitamin D₃

Guidance literature:: Multi-step reaction with 11 steps

1: 62 percent / pyridine / 0.5 h / 0 °C

2: 65 percent / dimethylsulfoxide / 4 h / 90 - 100 °C

3: potassium hydroxide / ethanol; H₂O / Heating

4: methanol; diethyl ether / 1 h / Ambient temperature

5: 77 percent / tetrahydrofuran / 2 h / 0 °C

6: 74 percent / tetrahydrofuran; aq. HCl; methanol / 2 h / Ambient temperature

7: 73 percent / pyridine / 16 h / Ambient temperature

8: N-bromosuccinimide / CCl₄ / 0.33 h / Heating

9: tetra-n-butylammonium fluoride / tetra-n-butylammonium bromide / tetrahydrofuran / Ambient temperature

10: potassium hydroxide / tetrahydrofuran; methanol / Ambient temperature

With pyridine; potassium hydroxide; N-Bromosuccinimide; tetrabutyl ammonium fluoride; tetrabutylammomium bromide; In tetrahydrofuran; hydrogenchloride; methanol; tetrachloromethane; diethyl ether; ethanol; water; dimethyl sulfoxide;
DOI:10.1248/cpb.36.2303

Reference yield:

: 70141-05-8
3β-tetrahydropyranyloxychol-5-en-24-yl cyanide

: 106372-47-8
25-hydroxy-26,27-dimethylvitamin D₃

Guidance literature:: Multi-step reaction with 9 steps

1: potassium hydroxide / ethanol; H₂O / Heating

2: methanol; diethyl ether / 1 h / Ambient temperature

3: 77 percent / tetrahydrofuran / 2 h / 0 °C

4: 74 percent / tetrahydrofuran; aq. HCl; methanol / 2 h / Ambient temperature

5: 73 percent / pyridine / 16 h / Ambient temperature

6: N-bromosuccinimide / CCl₄ / 0.33 h / Heating

7: tetra-n-butylammonium fluoride / tetra-n-butylammonium bromide / tetrahydrofuran / Ambient temperature

8: potassium hydroxide / tetrahydrofuran; methanol / Ambient temperature

With pyridine; potassium hydroxide; N-Bromosuccinimide; tetrabutyl ammonium fluoride; tetrabutylammomium bromide; In tetrahydrofuran; hydrogenchloride; methanol; tetrachloromethane; diethyl ether; ethanol; water;
DOI:10.1248/cpb.36.2303

Reference yield:

: 72341-35-6
(R)-5-[(3S,8S,9S,10R,13R,14S,17R)-10,13-Dimethyl-3-(tetrahydro-pyran-2-yloxy)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-hexanoic acid

: 106372-47-8
25-hydroxy-26,27-dimethylvitamin D₃

Guidance literature:: Multi-step reaction with 8 steps

1: methanol; diethyl ether / 1 h / Ambient temperature

2: 77 percent / tetrahydrofuran / 2 h / 0 °C

3: 74 percent / tetrahydrofuran; aq. HCl; methanol / 2 h / Ambient temperature

4: 73 percent / pyridine / 16 h / Ambient temperature

5: N-bromosuccinimide / CCl₄ / 0.33 h / Heating

6: tetra-n-butylammonium fluoride / tetra-n-butylammonium bromide / tetrahydrofuran / Ambient temperature

7: potassium hydroxide / tetrahydrofuran; methanol / Ambient temperature

With pyridine; potassium hydroxide; N-Bromosuccinimide; tetrabutyl ammonium fluoride; tetrabutylammomium bromide; In tetrahydrofuran; hydrogenchloride; methanol; tetrachloromethane; diethyl ether;
DOI:10.1248/cpb.36.2303