(S)-2-[Methyl-((S)-3-methyl-2-{methyl-[(S)-3-methyl-2-(methyl-{(S)-3-methyl-2-[methyl-((S)-2-methyl-oct-7-ynoyl)-amino]-butyryl}-amino)-butyryl]-amino}-butyryl)-amino]-3-phenyl-propionic acid tert-butyl ester

Base Information

Chemical Name:(S)-2-[Methyl-((S)-3-methyl-2-{methyl-[(S)-3-methyl-2-(methyl-{(S)-3-methyl-2-[methyl-((S)-2-methyl-oct-7-ynoyl)-amino]-butyryl}-amino)-butyryl]-amino}-butyryl)-amino]-3-phenyl-propionic acid tert-butyl ester
CAS No.:871733-05-0
Molecular Formula:C₄₁H₆₆N₄O₆
Molecular Weight:710.998
Hs Code.:

(S)-2-[Methyl-((S)-3-methyl-2-{methyl-[(S)-3-methyl-2-(methyl-{(S)-3-methyl-2-[methyl-((S)-2-methyl-oct-7-ynoyl)-amino]-butyryl}-amino)-butyryl]-amino}-butyryl)-amino]-3-phenyl-propionic acid tert-butyl ester

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Chemical Property of (S)-2-[Methyl-((S)-3-methyl-2-{methyl-[(S)-3-methyl-2-(methyl-{(S)-3-methyl-2-[methyl-((S)-2-methyl-oct-7-ynoyl)-amino]-butyryl}-amino)-butyryl]-amino}-butyryl)-amino]-3-phenyl-propionic acid tert-butyl ester

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Technology Process of (S)-2-[Methyl-((S)-3-methyl-2-{methyl-[(S)-3-methyl-2-(methyl-{(S)-3-methyl-2-[methyl-((S)-2-methyl-oct-7-ynoyl)-amino]-butyryl}-amino)-butyryl]-amino}-butyryl)-amino]-3-phenyl-propionic acid tert-butyl ester

There total 29 articles about (S)-2-[Methyl-((S)-3-methyl-2-{methyl-[(S)-3-methyl-2-(methyl-{(S)-3-methyl-2-[methyl-((S)-2-methyl-oct-7-ynoyl)-amino]-butyryl}-amino)-butyryl]-amino}-butyryl)-amino]-3-phenyl-propionic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (2S)-7-benzyloxy-2-methyl-heptanoic acid

: 871733-05-0
(S)-2-[Methyl-((S)-3-methyl-2-{methyl-[(S)-3-methyl-2-(methyl-{(S)-3-methyl-2-[methyl-((S)-2-methyl-oct-7-ynoyl)-amino]-butyryl}-amino)-butyryl]-amino}-butyryl)-amino]-3-phenyl-propionic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: diethyl ether

2.1: hydrogen / Pd/C / methanol / 4 h

3.1: oxalyl chloride; DMSO; triethylamine / CH₂Cl₂ / 1 h / -78 - -60 °C

4.1: K₂CO₃ / methanol / 0.5 h / 0 °C

4.2: methanol / 0 - 20 °C

5.1: LiOH*H₂O / tetrahydrofuran; H₂O / 12 h / 20 °C

6.1: BOPCl; DIPEA / CH₂Cl₂ / 16 h / 20 °C

With lithium hydroxide; oxalyl dichloride; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; potassium carbonate; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; 3.1: Swern oxidation;
DOI:10.1016/j.tet.2005.09.040

Reference yield:

: 871732-89-7
7-benzyloxy-heptanoic acid methyl ester

: 871733-05-0
(S)-2-[Methyl-((S)-3-methyl-2-{methyl-[(S)-3-methyl-2-(methyl-{(S)-3-methyl-2-[methyl-((S)-2-methyl-oct-7-ynoyl)-amino]-butyryl}-amino)-butyryl]-amino}-butyryl)-amino]-3-phenyl-propionic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 11 steps

1.1: 89 percent / LiOH*H₂O / tetrahydrofuran; H₂O / 12 h / 20 °C

2.1: oxalyl chloride; DMF / CH₂Cl₂ / 0 °C

3.1: DMAP; triethylamine / CH₂Cl₂ / 12 h / 20 °C

4.1: sodium bis(trimethylsilyl)amide / tetrahydrofuran / 0.75 h / -78 °C

4.2: tetrahydrofuran / 4 h / -78 °C

5.1: hydrogen peroxide; LiOH*H₂O / tetrahydrofuran; H₂O / 12 h / 20 °C

6.1: diethyl ether

7.1: hydrogen / Pd/C / methanol / 4 h

8.1: oxalyl chloride; DMSO; triethylamine / CH₂Cl₂ / 1 h / -78 - -60 °C

9.1: K₂CO₃ / methanol / 0.5 h / 0 °C

9.2: methanol / 0 - 20 °C

10.1: LiOH*H₂O / tetrahydrofuran; H₂O / 12 h / 20 °C

11.1: BOPCl; DIPEA / CH₂Cl₂ / 16 h / 20 °C

With dmap; lithium hydroxide; oxalyl dichloride; hydrogen; dihydrogen peroxide; sodium hexamethyldisilazane; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; potassium carbonate; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; 8.1: Swern oxidation;
DOI:10.1016/j.tet.2005.09.040

Reference yield:

: (2S)-7-benzyloxy-2-methyl-heptanoic acid methyl ester

: 871733-05-0
(S)-2-[Methyl-((S)-3-methyl-2-{methyl-[(S)-3-methyl-2-(methyl-{(S)-3-methyl-2-[methyl-((S)-2-methyl-oct-7-ynoyl)-amino]-butyryl}-amino)-butyryl]-amino}-butyryl)-amino]-3-phenyl-propionic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen / Pd/C / methanol / 4 h

2.1: oxalyl chloride; DMSO; triethylamine / CH₂Cl₂ / 1 h / -78 - -60 °C

3.1: K₂CO₃ / methanol / 0.5 h / 0 °C

3.2: methanol / 0 - 20 °C

4.1: LiOH*H₂O / tetrahydrofuran; H₂O / 12 h / 20 °C

5.1: BOPCl; DIPEA / CH₂Cl₂ / 16 h / 20 °C

With lithium hydroxide; oxalyl dichloride; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; potassium carbonate; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; water; 2.1: Swern oxidation;
DOI:10.1016/j.tet.2005.09.040