Boc-Leu-Aib-Pro-Val-Aib-Aib-Glu(OBzl)-Gln-Pheol

Base Information

Chemical Name:Boc-Leu-Aib-Pro-Val-Aib-Aib-Glu(OBzl)-Gln-Pheol
CAS No.:90508-31-9
Molecular Formula:C₅₉H₉₀N₁₀O₁₄
Molecular Weight:1163.42
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Boc-Leu-Aib-Pro-Val-Aib-Aib-Glu(OBzl)-Gln-Pheol

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of Boc-Leu-Aib-Pro-Val-Aib-Aib-Glu(OBzl)-Gln-Pheol

There total 12 articles about Boc-Leu-Aib-Pro-Val-Aib-Aib-Glu(OBzl)-Gln-Pheol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13139-15-6,53296-34-7
N-tert-butoxycarbonyl-L-leucine

: 90508-31-9
Boc-Leu-Aib-Pro-Val-Aib-Aib-Glu(OBzl)-Gln-Pheol

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) NMM, isobutyl chloroformate; 2.) NMM / 1.) methylene dichloride, DMF, -20 deg C, 10 min 2.) -15 deg C, 1 h; -5 deg C, 1 h; than to RT

2: 92 percent / acetic acid, H₂ / Pd/C / methanol; H₂O / 5 h / 30 - 35 °C

3: 1.) HOBt, DCC 2.) NMM / 1.) DMF, 37-40 deg C, 15-20 min 2.) 37-40 deg C, 1 h; RT, 12 h; 0 deg C, 1 h

4: 90 percent / 1N NaOH / methanol / Ambient temperature

5: 1.) HOBt, DCC; 2.) NMM / 1.) DMF, 0 deg C, 30 min 2.) RT, 15 h

6: 73 percent / 1N NaOH / methanol / 4 h / 30 - 35 °C

7: 1.) HOBt, DCC; 2.) NMM / 1.) DMF, 37-40 deg C, 20 min; 2.) RT, 20 h

With 4-methyl-morpholine; sodium hydroxide; hydrogen; benzotriazol-1-ol; acetic acid; dicyclohexyl-carbodiimide; isobutyl chloroformate; palladium on activated charcoal; In methanol; water;
DOI:10.1002/jlac.198519850210

Reference yield:

: 79118-23-3
Boc-Leu-Aib-OBzl

: 90508-31-9
Boc-Leu-Aib-Pro-Val-Aib-Aib-Glu(OBzl)-Gln-Pheol

Guidance literature:: Multi-step reaction with 6 steps

1: 92 percent / acetic acid, H₂ / Pd/C / methanol; H₂O / 5 h / 30 - 35 °C

2: 1.) HOBt, DCC 2.) NMM / 1.) DMF, 37-40 deg C, 15-20 min 2.) 37-40 deg C, 1 h; RT, 12 h; 0 deg C, 1 h

3: 90 percent / 1N NaOH / methanol / Ambient temperature

4: 1.) HOBt, DCC; 2.) NMM / 1.) DMF, 0 deg C, 30 min 2.) RT, 15 h

5: 73 percent / 1N NaOH / methanol / 4 h / 30 - 35 °C

6: 1.) HOBt, DCC; 2.) NMM / 1.) DMF, 37-40 deg C, 20 min; 2.) RT, 20 h

With 4-methyl-morpholine; sodium hydroxide; hydrogen; benzotriazol-1-ol; acetic acid; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; water;
DOI:10.1002/jlac.198519850210

Reference yield:

: 13734-41-3
t-Boc-L-valine

: 90508-31-9
Boc-Leu-Aib-Pro-Val-Aib-Aib-Glu(OBzl)-Gln-Pheol

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) NMM, isobutyl chloroformate; 2.) NMM / 1.) methylene dichloride, -15 deg C, 15 min 2.) -10 deg C, 30 min than to RT

2: 78 percent / 1.2N HCl, acetic acid / 0.5 h

3: 1.) HOBt, DCC; 2.) NMM / 1.) DMF, 0 deg C, 30 min 2.) RT, 15 h

4: 73 percent / 1N NaOH / methanol / 4 h / 30 - 35 °C

5: 1.) HOBt, DCC; 2.) NMM / 1.) DMF, 37-40 deg C, 20 min; 2.) RT, 20 h

With 4-methyl-morpholine; hydrogenchloride; sodium hydroxide; benzotriazol-1-ol; acetic acid; dicyclohexyl-carbodiimide; isobutyl chloroformate; In methanol;
DOI:10.1002/jlac.198519850210