Benzenemethanamine, .alpha.-butyl-N-methyl-

Base Information

• Chemical Name: Benzenemethanamine, .alpha.-butyl-N-methyl-
• CAS No.: 13509-75-6
• Molecular Formula: C12H19N
• Molecular Weight: 177.28600
• Hs Code.: 2921499090
• Mol file: 13509-75-6.mol

Synonyms:N-methyl-1-phenylpentan-1-amine;N-Methyl-N-(1-phenylpentyl)amin;1-Methylamino-1-phenyl-pentan;2-chloro-1-(3-methyl-3-phenylcyclobutyl) ethanone;methyl-(1-phenyl-pentyl)-amine;1-Phenyl-1-methylaminopentan;2-chloro-1-(3-methyl-3-phenylcyclobutyl)ethan-1-one;3-phenyl-3-methyl-1-(2-chloro-1-oxoethyl)cyclobutane;N-Methyl-1-phenylpentylamin;1-methyl-1-phenyl-3-(2-chloro-1-oxoethyl)cyclobutane;Ethanone,2-chloro-1-(3-methyl-3-phenylcyclobutyl);1-phenyl-1-methyl-3-(2-chloro-1-oxoethyl)cyclobutane;Methyl-(1-phenyl-pentyl)-amin;

Chemical Property of Benzenemethanamine, .alpha.-butyl-N-methyl-

Chemical Property:

• Boiling Point: 241℃
• PKA: 9.86±0.20(Predicted)
• Flash Point: 91℃
• PSA: 12.03000
• Density: 0.896
• LogP: 3.52820

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzenemethanamine, .alpha.-butyl-N-methyl-

There total 5 articles about Benzenemethanamine, .alpha.-butyl-N-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

n-butyl magnesium bromide (693-03-8) + N-methylbenzamide (88070-48-8) → N-methyl-1-phenylpentan-1-amine (13509-75-6)

Guidance literature:

N-methylbenzamide; With 2-fluoropyridine; trifluoromethylsulfonic anhydride; In dichloromethane; at -78 - 0 ℃; Inert atmosphere;

n-butyl magnesium bromide; With cerium(III) chloride heptahydrate; In tetrahydrofuran; dichloromethane; at -78 ℃; for 1h; Inert atmosphere;

With sodium tetrahydroborate; In tetrahydrofuran; methanol; dichloromethane; at 20 ℃; for 3h; Inert atmosphere;

DOI:10.1002/anie.201204098

Reference yield: 71.0%

n-butyllithium (109-72-8,29786-93-4) + N-benzyl-N-methyl triflamide (51029-13-1) → N-methyl-1-phenylpentan-1-amine (13509-75-6)

Guidance literature:

In tetrahydrofuran; at -60 ℃; for 3h;

DOI:10.1016/0040-4039(95)01266-K

Reference yield: 49.0%

1-iodo-butane (542-69-8) + N-Benzylidenemethylamine (622-29-7) → N-methyl-1-phenylpentan-1-amine (13509-75-6)

Guidance literature:

With strontium; In tetrahydrofuran; at 20 ℃; for 2h;

DOI:10.1246/cl.2005.760

upstream raw materials:

n-butyl magnesium bromide

N-Benzylidenemethylamine

n-butyllithium

N-benzyl-N-methyl triflamide

Refernces

• 1、 Huang, Pei-Qiang,Huang, Ying-Hong,Xiao, Kai-Jiong,Wang, Yu,Xia, Xiao-Er. "A general method for the one-pot reductive functionalization of secondary amides". . p. 2861 - 2868. Retrieved 2015/03/18.
• 2、 Miyoshi, Norikazu,Ikehara, Daitetsu,Kohno, Tadashi,Matsui, Aki,Wada, Makoto. "The chemistry of alkylstrontium halide analogues: Barbier-type alkylation of imines with alkyl halides". . p. 760 - 761. Retrieved 2007/10/03.