4-Morpholinecarboxylic acid, 2-[(phenylmethoxy)methyl]-, 1,1-dimethylethyl ester, (2R)-

Base Information

• Chemical Name: 4-Morpholinecarboxylic acid, 2-[(phenylmethoxy)methyl]-, 1,1-dimethylethyl ester, (2R)-
• CAS No.: 135097-68-6
• Molecular Formula: C17H25NO4
• Molecular Weight: 307.39
• Mol file: 135097-68-6.mol

Synonyms:tert-butyl (R)-2-((benzyloxy)methyl)morpholine-4-carboxylate;2R-benzyloxymethyl-morpholine-4-carboxylic acid tert-butyl ester;(R)-2-benzyloxymethylmorpholine-4-carboxylic acid tert-butyl ester;(2R)-benzyloxymethyl-morpholine-4-carboxylic acid tert-butyl ester;(R)-2-benzyloxymethyl-morpholine-4-carboxylic acid tert-butyl ester;(R)-2-(benzyloxymethyl)morpholine-4-carboxylic acid tert-butyl ester;

Chemical Property of 4-Morpholinecarboxylic acid, 2-[(phenylmethoxy)methyl]-, 1,1-dimethylethyl ester, (2R)-

Chemical Property:

• PSA: 48.00000
• LogP: 2.77700

Purity/Quality:

99% ^*data from raw suppliers

(R)-tert-Butyl2-((benzyloxy)methyl)morpholine-4-carboxylate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Morpholinecarboxylic acid, 2-[(phenylmethoxy)methyl]-, 1,1-dimethylethyl ester, (2R)-

There total 3 articles about 4-Morpholinecarboxylic acid, 2-[(phenylmethoxy)methyl]-, 1,1-dimethylethyl ester, (2R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

di-tert-butyl dicarbonate (24424-99-5) + (2R)-2-[(benzyloxy)methyl]morpholine (135065-70-2) → tert-butyl (2R)-2-[(benzyloxy)methyl]morpholine-4-carboxylate (135097-68-6)

Guidance literature:

With triethylamine; In dichloromethane; at 20 - 25 ℃; for 2h;

Reference yield:

(R)-benzyl glycidol (14618-80-5) → tert-butyl (2R)-2-[(benzyloxy)methyl]morpholine-4-carboxylate (135097-68-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 62 percent / NaOH / H₂O / 21 h / 50 - 55 °C

2: 88 percent / Et₃N / CH₂Cl₂ / 2 h / 20 - 25 °C

With sodium hydroxide; triethylamine; In dichloromethane; water;

Reference yield:

C12H19NO6S → tert-butyl (2R)-2-[(benzyloxy)methyl]morpholine-4-carboxylate (135097-68-6)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / water; toluene / 16 h / 65 °C

2: potassium carbonate / water; acetone / 0.5 h / 0 - 20 °C

With potassium carbonate; sodium hydroxide; In water; acetone; toluene;

DOI:10.1016/j.bmcl.2011.06.043

upstream raw materials:

di-tert-butyl dicarbonate

(2R)-2-[(benzyloxy)methyl]morpholine

(R)-benzyl glycidol

Downstream raw materials:

(R)-2-hydroxymethylmorpholine-4-carboxylic acid tert-butyl ester

tert-butyl (2R)-2-({[(4-methylphenyl)sulfonyl]oxy}methyl)morpholine-4-carboxylate

tert-butyl (2S)-2-({[(4-methylphenyl)sulfonyl]oxy}methyl)morpholine-4-carboxylate

(R)-4-tert-butoxycarbonyl-2-p-nitrobenzenesulfonyloxymethylmorpholine