methyl (6-formyl-2,2-dimethylcyclohexyl)acetate

Base Information

• Chemical Name: methyl (6-formyl-2,2-dimethylcyclohexyl)acetate
• CAS No.: 150018-01-2
• Molecular Formula: C₁₂H₂₀O₃
• Molecular Weight: 212.289
• Mol file: 150018-01-2.mol

Synonyms:

Chemical Property of methyl (6-formyl-2,2-dimethylcyclohexyl)acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl (6-formyl-2,2-dimethylcyclohexyl)acetate

There total 1 articles about methyl (6-formyl-2,2-dimethylcyclohexyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

dimethyl (2E,9E)-4,4-dimethylundeca-2,9-dienedicarboxylate (154436-76-7) → methyl (2,2-dimethyl-6-oxocyclohexyl)acetate (150018-00-1) + methyl (6-formyl-2,2-dimethylcyclohexyl)acetate (150018-01-2)

Guidance literature:

With t-butyldimethylsiyl triflate; ozone; triethylamine; Yield given. Multistep reaction. Yields of byproduct given; 1.) CH₂Cl₂, RT, 2.) CH₂Cl₂, -78 deg C;

DOI:10.1039/C39930000755

Reference yield:

methyl (6-formyl-2,2-dimethylcyclohexyl)acetate (150018-01-2) → 3-<2-(2-Hydroxymethyl-6,6-dimethylcyclohexyl)-1-hydroxyethyl>furan (139137-87-4,150132-20-0,150132-21-1)

Guidance literature:

Multi-step reaction with 6 steps

1: 99 percent / NaBH₄ / ethanol / 0.17 h / -8 °C

2: 97 percent / BF₃*OEt₂ / CH₂Cl₂ / 1 h / Ambient temperature

3: 100 percent / 2,6-dimethylpyridine / CH₂Cl₂ / 0.42 h / 18 °C

4: NaHCO₃, MeI / acetonitrile; H₂O / 23 h / 45 °C

5: BuLi / tetrahydrofuran; hexane / 1 h / -78 °C

6: Bu₄NF / tetrahydrofuran / 1 h / 0 °C

With 2,6-dimethylpyridine; sodium tetrahydroborate; n-butyllithium; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; sodium hydrogencarbonate; methyl iodide; In tetrahydrofuran; ethanol; hexane; dichloromethane; water; acetonitrile;

DOI:10.1039/P19930002251

Reference yield:

methyl (6-formyl-2,2-dimethylcyclohexyl)acetate (150018-01-2) → 2-<2-(3-furyl)-2-oxoethyl>-2,2-dimethylcyclohexanecarboxylic acid (139137-80-7)

Guidance literature:

Multi-step reaction with 7 steps

1: 99 percent / NaBH₄ / ethanol / 0.17 h / -8 °C

2: 97 percent / BF₃*OEt₂ / CH₂Cl₂ / 1 h / Ambient temperature

3: 100 percent / 2,6-dimethylpyridine / CH₂Cl₂ / 0.42 h / 18 °C

4: NaHCO₃, MeI / acetonitrile; H₂O / 23 h / 45 °C

5: BuLi / tetrahydrofuran; hexane / 1 h / -78 °C

6: Bu₄NF / tetrahydrofuran / 1 h / 0 °C

7: 23 percent / PDC / dimethylformamide / 70 h / Ambient temperature

With 2,6-dimethylpyridine; sodium tetrahydroborate; dipyridinium dichromate; n-butyllithium; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; sodium hydrogencarbonate; methyl iodide; In tetrahydrofuran; ethanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1039/P19930002251

upstream raw materials:

dimethyl (2E,9E)-4,4-dimethylundeca-2,9-dienedicarboxylate

Downstream raw materials:

3-<2-(2-Hydroxymethyl-6,6-dimethylcyclohexyl)-1-hydroxyethyl>furan

2-<2-(3-furyl)-2-oxoethyl>-2,2-dimethylcyclohexanecarboxylic acid