4-hydroxy-4-[4-phenyl-1-(2-trimethylsilanyloxy-ethyl)-1H-imidazol-2-yl]-piperidine-1-carboxylic acid tert-butyl ester

Base Information

• Chemical Name: 4-hydroxy-4-[4-phenyl-1-(2-trimethylsilanyloxy-ethyl)-1H-imidazol-2-yl]-piperidine-1-carboxylic acid tert-butyl ester
• CAS No.: 737766-55-1
• Molecular Formula: C₂₄H₃₇N₃O₄Si
• Molecular Weight: 459.661
• Mol file: 737766-55-1.mol

Synonyms:

Chemical Property of 4-hydroxy-4-[4-phenyl-1-(2-trimethylsilanyloxy-ethyl)-1H-imidazol-2-yl]-piperidine-1-carboxylic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-hydroxy-4-[4-phenyl-1-(2-trimethylsilanyloxy-ethyl)-1H-imidazol-2-yl]-piperidine-1-carboxylic acid tert-butyl ester

There total 1 articles about 4-hydroxy-4-[4-phenyl-1-(2-trimethylsilanyloxy-ethyl)-1H-imidazol-2-yl]-piperidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-tert-butyloxycarbonylpiperidin-4-one (79099-07-3) + 4-phenyl-1-(2-trimethylsilanyloxy-ethyl)-1H-imidazole → 4-hydroxy-4-[4-phenyl-1-(2-trimethylsilanyloxy-ethyl)-1H-imidazol-2-yl]-piperidine-1-carboxylic acid tert-butyl ester (737766-55-1)

Guidance literature:

4-phenyl-1-(2-trimethylsilanyloxy-ethyl)-1H-imidazole; With n-butyllithium; In tetrahydrofuran;

N-tert-butyloxycarbonylpiperidin-4-one; In tetrahydrofuran;

DOI:10.1016/j.bmcl.2004.04.078

Reference yield:

4-hydroxy-4-[4-phenyl-1-(2-trimethylsilanyloxy-ethyl)-1H-imidazol-2-yl]-piperidine-1-carboxylic acid tert-butyl ester (737766-55-1) → 4-(4-phenyl-1H-imidazol-2-yl)piperidine (737766-57-3)

Guidance literature:

Multi-step reaction with 4 steps

1: MsCl; DIPEA / CH₂Cl₂

2: H₂ / PtO₂ / ethanol

3: TBAF / tetrahydrofuran

4: HCl / methanol

With hydrogenchloride; tetrabutyl ammonium fluoride; hydrogen; methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine; platinum(IV) oxide; In tetrahydrofuran; methanol; ethanol; dichloromethane;

DOI:10.1016/j.bmcl.2004.04.078

Reference yield:

4-hydroxy-4-[4-phenyl-1-(2-trimethylsilanyloxy-ethyl)-1H-imidazol-2-yl]-piperidine-1-carboxylic acid tert-butyl ester (737766-55-1) → tert-butyl 4-(4-phenyl-1H-imidazol-2-yl)piperidine-1-carboxylate

Guidance literature:

Multi-step reaction with 3 steps

1: MsCl; DIPEA / CH₂Cl₂

2: H₂ / PtO₂ / ethanol

3: TBAF / tetrahydrofuran

With tetrabutyl ammonium fluoride; hydrogen; methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine; platinum(IV) oxide; In tetrahydrofuran; ethanol; dichloromethane;

DOI:10.1016/j.bmcl.2004.04.078

upstream raw materials:

N-tert-butyloxycarbonylpiperidin-4-one

Downstream raw materials:

4-(4-phenyl-1H-imidazol-2-yl)piperidine

4-[4-phenyl-1-(2-trimethylsilanyloxy-ethyl)-1H-imidazol-2-yl]-piperidine-1-carboxylic acid tert-butyl ester