(S)-11-(4-Dimethylamino-2-methoxy-phenyl)-9-((S)-2-ethyl-1,4-dioxa-spiro[4.5]dec-2-ylmethyl)-5,8,9,10,11,12-hexahydro-6H-7,12-diaza-cyclonona[a]indene-7,11-dicarboxylic acid 11-methyl ester 7-(4-nitro-benzyl) ester

Base Information

Chemical Name:(S)-11-(4-Dimethylamino-2-methoxy-phenyl)-9-((S)-2-ethyl-1,4-dioxa-spiro[4.5]dec-2-ylmethyl)-5,8,9,10,11,12-hexahydro-6H-7,12-diaza-cyclonona[a]indene-7,11-dicarboxylic acid 11-methyl ester 7-(4-nitro-benzyl) ester
CAS No.:141521-26-8
Molecular Formula:C₄₄H₅₄N₄O₉
Molecular Weight:782.934
Hs Code.:

(S)-11-(4-Dimethylamino-2-methoxy-phenyl)-9-((S)-2-ethyl-1,4-dioxa-spiro[4.5]dec-2-ylmethyl)-5,8,9,10,11,12-hexahydro-6H-7,12-diaza-cyclonona[a]indene-7,11-dicarboxylic acid 11-methyl ester 7-(4-nitro-benzyl) ester

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Chemical Property of (S)-11-(4-Dimethylamino-2-methoxy-phenyl)-9-((S)-2-ethyl-1,4-dioxa-spiro[4.5]dec-2-ylmethyl)-5,8,9,10,11,12-hexahydro-6H-7,12-diaza-cyclonona[a]indene-7,11-dicarboxylic acid 11-methyl ester 7-(4-nitro-benzyl) ester

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Technology Process of (S)-11-(4-Dimethylamino-2-methoxy-phenyl)-9-((S)-2-ethyl-1,4-dioxa-spiro[4.5]dec-2-ylmethyl)-5,8,9,10,11,12-hexahydro-6H-7,12-diaza-cyclonona[a]indene-7,11-dicarboxylic acid 11-methyl ester 7-(4-nitro-benzyl) ester

There total 11 articles about (S)-11-(4-Dimethylamino-2-methoxy-phenyl)-9-((S)-2-ethyl-1,4-dioxa-spiro[4.5]dec-2-ylmethyl)-5,8,9,10,11,12-hexahydro-6H-7,12-diaza-cyclonona[a]indene-7,11-dicarboxylic acid 11-methyl ester 7-(4-nitro-benzyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 15799-79-8
3-methoxy-N,N-dimethylaniline

: 129895-92-7,129941-19-1,130007-82-8,144666-10-4
(-)-(9R,2S,2'S)-3H-9-(methoxycarbonyl)-2-(2'-ethyl-2',3'dihydroxypropyl)hexahydroindolizino<8,7-b>indole cyclohexylidene ketal

: 4457-32-3
4-nitrobenzyl chloroformate

: 141521-26-8,141554-42-9
(S)-11-(4-Dimethylamino-2-methoxy-phenyl)-9-((S)-2-ethyl-1,4-dioxa-spiro[4.5]dec-2-ylmethyl)-5,8,9,10,11,12-hexahydro-6H-7,12-diaza-cyclonona[a]indene-7,11-dicarboxylic acid 11-methyl ester 7-(4-nitro-benzyl) ester

Guidance literature:: With 2,6-di-tert-butyl-4-methylpyridine; In nitromethane; at 23 ℃; for 96h;
DOI:10.1016/S0040-4039(00)91570-3

Reference yield:

: 121464-71-9
(R)-(2-ethoxyoxiran-2-yl)methanol

: 141521-26-8,141554-42-9
(S)-11-(4-Dimethylamino-2-methoxy-phenyl)-9-((S)-2-ethyl-1,4-dioxa-spiro[4.5]dec-2-ylmethyl)-5,8,9,10,11,12-hexahydro-6H-7,12-diaza-cyclonona[a]indene-7,11-dicarboxylic acid 11-methyl ester 7-(4-nitro-benzyl) ester

Guidance literature:: Multi-step reaction with 9 steps

1: 1.0N aq.NaOH / dioxane / Heating

2: H₃O+

3: 94 percent / MCPBA

4: 1) Ac2O, NaOAc, 2) K2CO3 / 1) Δ, 2) MeOH, Δ

5: 80 percent / Sn(OTf)2, N-ethylpiperidine / tetrahydrofuran

6: 97 percent / NEt₃

7: 93 percent / DBU / CH₂Cl₂

8: Raney nickel

9: 73 percent / 2,6-di-tert-butyl-4-methylpyridine / nitromethane / 96 h / 23 °C

With 1-ethyl-piperidine; sodium hydroxide; tin(II) trifluoromethanesulfonate; 2,6-di-tert-butyl-4-methylpyridine; oxonium; sodium acetate; acetic anhydride; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; 3-chloro-benzenecarboperoxoic acid; nickel; In tetrahydrofuran; 1,4-dioxane; nitromethane; dichloromethane;
DOI:10.1016/S0040-4039(00)91570-3

Reference yield:

: 141521-24-6
(+)-(9R,2'S)-3-thioxo-9-(methoxycarbonyl)-2-(2'-ethyl-2',3'dihydroxypropenyl)hexahydroindolizino<8,7-b>indole cyclohexylidene ketal

: 141521-26-8,141554-42-9
(S)-11-(4-Dimethylamino-2-methoxy-phenyl)-9-((S)-2-ethyl-1,4-dioxa-spiro[4.5]dec-2-ylmethyl)-5,8,9,10,11,12-hexahydro-6H-7,12-diaza-cyclonona[a]indene-7,11-dicarboxylic acid 11-methyl ester 7-(4-nitro-benzyl) ester

Guidance literature:: Multi-step reaction with 2 steps

1: Raney nickel

2: 73 percent / 2,6-di-tert-butyl-4-methylpyridine / nitromethane / 96 h / 23 °C

With 2,6-di-tert-butyl-4-methylpyridine; nickel; In nitromethane;
DOI:10.1016/S0040-4039(00)91570-3