cis-2-(phenylseleno)-3-benzoylcyclohexanone

Base Information

• Chemical Name: cis-2-(phenylseleno)-3-benzoylcyclohexanone
• CAS No.: 100514-96-3
• Molecular Formula: C₁₉H₁₈O₂Se
• Molecular Weight: 357.311
• Mol file: 100514-96-3.mol

Synonyms:

Chemical Property of cis-2-(phenylseleno)-3-benzoylcyclohexanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of cis-2-(phenylseleno)-3-benzoylcyclohexanone

There total 3 articles about cis-2-(phenylseleno)-3-benzoylcyclohexanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(N,N-dimethylamino)-2-phenylacetonitrile (827-36-1) → cis-2-(phenylseleno)-3-benzoylcyclohexanone (100514-96-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) n-BuLi / 1.) THF, -78 deg C, 15 min, 2.) THF, -78 deg C, 40 min

2: 0.5 N aq. AgNO₃ / tetrahydrofuran; diethyl ether / 0.67 h / Ambient temperature

With n-butyllithium; silver nitrate; In tetrahydrofuran; diethyl ether;

DOI:10.1021/jo00358a024

Reference yield:

2-(phenylselanyl)cyclohex-2-en-1-one (57204-95-2) → cis-2-(phenylseleno)-3-benzoylcyclohexanone (100514-96-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) n-BuLi / 1.) THF, -78 deg C, 15 min, 2.) THF, -78 deg C, 40 min

2: 0.5 N aq. AgNO₃ / tetrahydrofuran; diethyl ether / 0.67 h / Ambient temperature

With n-butyllithium; silver nitrate; In tetrahydrofuran; diethyl ether;

DOI:10.1021/jo00358a024

Reference yield:

cis-2-(phenylseleno)-3-cyclohexanone (100514-93-0) → 3-benzoylcyclohex-2-en-1-one (100515-02-4) + cis-2-(phenylseleno)-3-benzoylcyclohexanone (100514-96-3) + trans-2-(phenylseleno)-3-benzoylcyclohexanone (100514-95-2)

Guidance literature:

With silver nitrate; In tetrahydrofuran; diethyl ether; for 0.666667h; Title compound not separated from byproducts; Ambient temperature;

DOI:10.1021/jo00358a024

upstream raw materials:

cis-2-(phenylseleno)-3-cyclohexanone

2-(N,N-dimethylamino)-2-phenylacetonitrile

2-(phenylselanyl)cyclohex-2-en-1-one