Technology Process of (5Z,8Z,11Z,14Z)-19-Iodononadeca-5,8,11,14-tetraenoic acid
There total 10 articles about (5Z,8Z,11Z,14Z)-19-Iodononadeca-5,8,11,14-tetraenoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 10 steps
1: 72 percent / CBr4; PPh3 / CH2Cl2; dimethylformamide / 1 h / 0 - 10 °C
2: 80 percent / CuI; NaI; K2CO3 / dimethylformamide / 20 °C
3: 81 percent / H2; quinoline / 5 percent Pd/CaCO3 / benzene / 1 h / 10 °C
4: 89 percent / LiOH; H2O / methanol / 8 h / 20 °C
5: diethyl ether
6: oxalyl chloride / CH2Cl2 / 0.5 h / 10 °C
7: NaBH4 / acetonitrile / 3 h / 20 °C
8: CCl4; PPh3 / CH2Cl2 / 24 h / 20 °C
9: LiOH; H2O / methanol / 20 °C
10: 89 percent / NaI / acetone / 20 h / 65 °C
With
quinoline; tetrachloromethane; lithium hydroxide; sodium tetrahydroborate; copper(l) iodide; oxalyl dichloride; carbon tetrabromide; water; hydrogen; potassium carbonate; triphenylphosphine; sodium iodide;
Lindlar's catalyst;
In
methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; acetone; acetonitrile; benzene;
1: Substitution / 2: Alkylation / 3: Catalytic hydrogenation / 4: Hydrolysis / 5: Esterification / 6: Substitution / 7: Reduction / 8: Substitution / 9: Hydrolysis / 10: Substitution;
DOI:10.1055/s-2000-6400
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 80 percent / CuI; NaI; K2CO3 / dimethylformamide / 20 °C
2: 81 percent / H2; quinoline / 5 percent Pd/CaCO3 / benzene / 1 h / 10 °C
3: 89 percent / LiOH; H2O / methanol / 8 h / 20 °C
4: diethyl ether
5: oxalyl chloride / CH2Cl2 / 0.5 h / 10 °C
6: NaBH4 / acetonitrile / 3 h / 20 °C
7: CCl4; PPh3 / CH2Cl2 / 24 h / 20 °C
8: LiOH; H2O / methanol / 20 °C
9: 89 percent / NaI / acetone / 20 h / 65 °C
With
quinoline; tetrachloromethane; lithium hydroxide; sodium tetrahydroborate; copper(l) iodide; oxalyl dichloride; water; hydrogen; potassium carbonate; triphenylphosphine; sodium iodide;
Lindlar's catalyst;
In
methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; acetone; acetonitrile; benzene;
1: Alkylation / 2: Catalytic hydrogenation / 3: Hydrolysis / 4: Esterification / 5: Substitution / 6: Reduction / 7: Substitution / 8: Hydrolysis / 9: Substitution;
DOI:10.1055/s-2000-6400
