3-(1H-indazol-3-yl)benzoic acid

Base Information

• Chemical Name: 3-(1H-indazol-3-yl)benzoic acid
• CAS No.: 1018788-86-7
• Molecular Formula: C₁₄H₁₀N₂O₂
• Molecular Weight: 238.246
• Mol file: 1018788-86-7.mol

Synonyms:

Chemical Property of 3-(1H-indazol-3-yl)benzoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(1H-indazol-3-yl)benzoic acid

There total 3 articles about 3-(1H-indazol-3-yl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[3-(methoxycarbonyl)phenyl]boronic acid (99769-19-4) → 3-(1H-indazol-3-yl)benzoic acid (1018788-86-7)

Guidance literature:

Multi-step reaction with 3 steps

1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium phosphate / 1,4-dioxane; water / 1 h / 90 °C / Inert atmosphere; Microwave irradiation

2: trifluoroacetic acid / dichloromethane / 16 h / 20 °C

3: water; sodium hydroxide / methanol; tetrahydrofuran / 16 h / 20 °C

With potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; water; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; 1: |Suzuki Coupling;

DOI:10.1002/cmdc.201900019

Reference yield:

tert-butyl 3-(3-(methoxycarbonyl)phenyl)-1H-indazole-1-carboxylate → 3-(1H-indazol-3-yl)benzoic acid (1018788-86-7)

Guidance literature:

Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 16 h / 20 °C

2: water; sodium hydroxide / methanol; tetrahydrofuran / 16 h / 20 °C

With water; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1002/cmdc.201900019

Reference yield:

tert-butyl 3-iodo-1H-indazole-1-carboxylate (290368-00-2) → 3-(1H-indazol-3-yl)benzoic acid (1018788-86-7)

Guidance literature:

Multi-step reaction with 3 steps

1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium phosphate / 1,4-dioxane; water / 1 h / 90 °C / Inert atmosphere; Microwave irradiation

2: trifluoroacetic acid / dichloromethane / 16 h / 20 °C

3: water; sodium hydroxide / methanol; tetrahydrofuran / 16 h / 20 °C

With potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; water; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; 1: |Suzuki Coupling;

DOI:10.1002/cmdc.201900019

upstream raw materials:

[3-(methoxycarbonyl)phenyl]boronic acid

tert-butyl 3-iodo-1H-indazole-1-carboxylate

Downstream raw materials:

ethyl 3-(1H-indazol-3-yl)benzoic acid