Technology Process of (+)-(1'S,5'S)-methyl 3-(5'-acetoxy-2',6',6'-trimethyl-2'-cyclohexenyl)propionate
There total 17 articles about (+)-(1'S,5'S)-methyl 3-(5'-acetoxy-2',6',6'-trimethyl-2'-cyclohexenyl)propionate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 13 steps
1: LiAlH4 / diethyl ether / 1.) 1 h, reflux, 2.) 1.5 h, r.t.
2: acetic acid / H2O / 1 h / 60 °C
3: pyridine / 72 h / Ambient temperature
4: 1.) H2, 2.) CrO3, conc. H2SO4 / 1.) 5percent Rh/C / 1.) EtOH, 46 h, 2.) H2O, acetone
6: diethyl ether / 0.5 h / Ambient temperature
8: pyridine
9: 70 percent / Na2HPO4, trifluoroperacetic acid / CH2Cl2
10: 5percent aq. KOH / ethanol / 20 h / 60 °C
11: diethyl ether
12: pyridine / 50 °C
13: thionyl chloride, pyridine
With
pyridine; chromium(VI) oxide; potassium hydroxide; disodium hydrogenphosphate; lithium aluminium tetrahydride; thionyl chloride; trifluoroacetyl peroxide; sulfuric acid; hydrogen; acetic acid;
Rh on carbon;
In
diethyl ether; ethanol; dichloromethane; water;
DOI:10.1002/hlca.19810640402
- Guidance literature:
-
Multi-step reaction with 11 steps
1: pyridine / 72 h / Ambient temperature
2: 1.) H2, 2.) CrO3, conc. H2SO4 / 1.) 5percent Rh/C / 1.) EtOH, 46 h, 2.) H2O, acetone
4: diethyl ether / 0.5 h / Ambient temperature
6: pyridine
7: 70 percent / Na2HPO4, trifluoroperacetic acid / CH2Cl2
8: 5percent aq. KOH / ethanol / 20 h / 60 °C
9: diethyl ether
10: pyridine / 50 °C
11: thionyl chloride, pyridine
With
pyridine; chromium(VI) oxide; potassium hydroxide; disodium hydrogenphosphate; thionyl chloride; trifluoroacetyl peroxide; sulfuric acid; hydrogen;
Rh on carbon;
In
diethyl ether; ethanol; dichloromethane;
DOI:10.1002/hlca.19810640402
- Guidance literature:
-
Multi-step reaction with 12 steps
1: acetic acid / H2O / 1 h / 60 °C
2: pyridine / 72 h / Ambient temperature
3: 1.) H2, 2.) CrO3, conc. H2SO4 / 1.) 5percent Rh/C / 1.) EtOH, 46 h, 2.) H2O, acetone
5: diethyl ether / 0.5 h / Ambient temperature
7: pyridine
8: 70 percent / Na2HPO4, trifluoroperacetic acid / CH2Cl2
9: 5percent aq. KOH / ethanol / 20 h / 60 °C
10: diethyl ether
11: pyridine / 50 °C
12: thionyl chloride, pyridine
With
pyridine; chromium(VI) oxide; potassium hydroxide; disodium hydrogenphosphate; thionyl chloride; trifluoroacetyl peroxide; sulfuric acid; hydrogen; acetic acid;
Rh on carbon;
In
diethyl ether; ethanol; dichloromethane; water;
DOI:10.1002/hlca.19810640402
