Toluene-4-sulfonic acid (R)-2-((1R,7aR)-4-benzenesulfonyl-5-hydroxy-7a-methyl-2,3,5,6,7,7a-hexahydro-1H-inden-1-yl)-4-((S)-2,2,5,5-tetramethyl-[1,3]dioxolan-4-yl)-butyl ester

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Chemical Name:Toluene-4-sulfonic acid (R)-2-((1R,7aR)-4-benzenesulfonyl-5-hydroxy-7a-methyl-2,3,5,6,7,7a-hexahydro-1H-inden-1-yl)-4-((S)-2,2,5,5-tetramethyl-[1,3]dioxolan-4-yl)-butyl ester
CAS No.:203392-61-4
Molecular Formula:C₃₄H₄₆O₈S₂
Molecular Weight:646.866
Hs Code.:

Toluene-4-sulfonic acid (R)-2-((1R,7aR)-4-benzenesulfonyl-5-hydroxy-7a-methyl-2,3,5,6,7,7a-hexahydro-1H-inden-1-yl)-4-((S)-2,2,5,5-tetramethyl-[1,3]dioxolan-4-yl)-butyl ester

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Chemical Property of Toluene-4-sulfonic acid (R)-2-((1R,7aR)-4-benzenesulfonyl-5-hydroxy-7a-methyl-2,3,5,6,7,7a-hexahydro-1H-inden-1-yl)-4-((S)-2,2,5,5-tetramethyl-[1,3]dioxolan-4-yl)-butyl ester

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Technology Process of Toluene-4-sulfonic acid (R)-2-((1R,7aR)-4-benzenesulfonyl-5-hydroxy-7a-methyl-2,3,5,6,7,7a-hexahydro-1H-inden-1-yl)-4-((S)-2,2,5,5-tetramethyl-[1,3]dioxolan-4-yl)-butyl ester

There total 8 articles about Toluene-4-sulfonic acid (R)-2-((1R,7aR)-4-benzenesulfonyl-5-hydroxy-7a-methyl-2,3,5,6,7,7a-hexahydro-1H-inden-1-yl)-4-((S)-2,2,5,5-tetramethyl-[1,3]dioxolan-4-yl)-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 203392-53-4
(S)-6-Hydroxy-7,7-dimethyl-oxepan-2-one

: 203392-61-4
Toluene-4-sulfonic acid (R)-2-((1R,7aR)-4-benzenesulfonyl-5-hydroxy-7a-methyl-2,3,5,6,7,7a-hexahydro-1H-inden-1-yl)-4-((S)-2,2,5,5-tetramethyl-[1,3]dioxolan-4-yl)-butyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) AlMe₃; 2.) TsOH

2: 92 percent / lithium diisopropylamide / -78 deg C to RT

3: TrSbCl₆ / CH₂Cl₂ / -78 °C

4: CH₂Cl₂

5: 84 percent / KOH / methanol

6: DIBAL-H / CH₂Cl₂ / -78 °C

7: Et₃N

8: MCPBA

With potassium hydroxide; trimethylaluminum; triphenylmethylium hexachloroantimonate(V); diisobutylaluminium hydride; toluene-4-sulfonic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; lithium diisopropyl amide; In methanol; dichloromethane;
DOI:10.1016/S0040-4039(97)10647-5

Reference yield:

: 203392-54-5
S-tert-butyl 4-[(3S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl]butanethioate

: 203392-61-4
Toluene-4-sulfonic acid (R)-2-((1R,7aR)-4-benzenesulfonyl-5-hydroxy-7a-methyl-2,3,5,6,7,7a-hexahydro-1H-inden-1-yl)-4-((S)-2,2,5,5-tetramethyl-[1,3]dioxolan-4-yl)-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 92 percent / lithium diisopropylamide / -78 deg C to RT

2: TrSbCl₆ / CH₂Cl₂ / -78 °C

3: CH₂Cl₂

4: 84 percent / KOH / methanol

5: DIBAL-H / CH₂Cl₂ / -78 °C

6: Et₃N

7: MCPBA

With potassium hydroxide; triphenylmethylium hexachloroantimonate(V); diisobutylaluminium hydride; triethylamine; 3-chloro-benzenecarboperoxoic acid; lithium diisopropyl amide; In methanol; dichloromethane;
DOI:10.1016/S0040-4039(97)10647-5

Reference yield:

: 203392-55-6
(1E/Z)-1-(tert-butylthio)-4-[(4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl]-1-trimethylsilyloxy-but-1-ene

: 203392-61-4
Toluene-4-sulfonic acid (R)-2-((1R,7aR)-4-benzenesulfonyl-5-hydroxy-7a-methyl-2,3,5,6,7,7a-hexahydro-1H-inden-1-yl)-4-((S)-2,2,5,5-tetramethyl-[1,3]dioxolan-4-yl)-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: TrSbCl₆ / CH₂Cl₂ / -78 °C

2: CH₂Cl₂

3: 84 percent / KOH / methanol

4: DIBAL-H / CH₂Cl₂ / -78 °C

5: Et₃N

6: MCPBA

With potassium hydroxide; triphenylmethylium hexachloroantimonate(V); diisobutylaluminium hydride; triethylamine; 3-chloro-benzenecarboperoxoic acid; In methanol; dichloromethane;
DOI:10.1016/S0040-4039(97)10647-5