rac-<2R,3S(R)>-6,8-difluoro-1-(2-fluoroethyl)-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid <<3-<1-<(trimethylsilyl)oxy>ethyl>-1-<2-<(2,2-dimethyl-1-oxopropoxy)methoxy>-2-oxo-1-(triphenylphosphoranylidene)etyl>-4-oxo-2-azeti.>>

Base Information

• Chemical Name: rac-<2R,3S(R)>-6,8-difluoro-1-(2-fluoroethyl)-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid <<3-<1-<(trimethylsilyl)oxy>ethyl>-1-<2-<(2,2-dimethyl-1-oxopropoxy)methoxy>-2-oxo-1-(triphenylphosphoranylidene)etyl>-4-oxo-2-azeti.>>
• CAS No.: 140928-19-4
• Molecular Formula: C₅₄H₆₂F₃N₄O₁₀PSi
• Molecular Weight: 1043.16

Synonyms:

Chemical Property of rac-<2R,3S(R)>-6,8-difluoro-1-(2-fluoroethyl)-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid <<3-<1-<(trimethylsilyl)oxy>ethyl>-1-<2-<(2,2-dimethyl-1-oxopropoxy)methoxy>-2-oxo-1-(triphenylphosphoranylidene)etyl>-4-oxo-2-azeti.>>

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of rac-<2R,3S(R)>-6,8-difluoro-1-(2-fluoroethyl)-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid <<3-<1-<(trimethylsilyl)oxy>ethyl>-1-<2-<(2,2-dimethyl-1-oxopropoxy)methoxy>-2-oxo-1-(triphenylphosphoranylidene)etyl>-4-oxo-2-azeti.>>

There total 3 articles about rac-<2R,3S(R)>-6,8-difluoro-1-(2-fluoroethyl)-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid <<3-<1-<(trimethylsilyl)oxy>ethyl>-1-<2-<(2,2-dimethyl-1-oxopropoxy)methoxy>-2-oxo-1-(triphenylphosphoranylidene)etyl>-4-oxo-2-azeti.>> which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6,8-difluoro-1-(2-fluoroethyl)-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid potassium salt (115699-47-3) → rac-<2R,3S(R)>-6,8-difluoro-1-(2-fluoroethyl)-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid <<3-<1-<(trimethylsilyl)oxy>ethyl>-1-<2-<(2,2-dimethyl-1-oxopropoxy)methoxy>-2-oxo-1-(triphenylphosphoranylidene)etyl>-4-oxo-2-azeti.>> (140928-19-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 63 percent / Et₃N / dimethylformamide / 17 h / Ambient temperature

2: pyridine / 22 h / Ambient temperature

With pyridine; triethylamine; In N,N-dimethyl-formamide;

DOI:10.1021/jm00088a019

Reference yield:

rac-<2R,3S(R)>-2-(3-bromo-2-oxopropyl)-3-(1-hydroxyethyl)-4-oxo-α-(triphenylphosphoranylidene)azetidine-1-acetic acid (2,2-dimethyl-1-oxopropoxy)methyl ester (138423-45-7) → rac-<2R,3S(R)>-6,8-difluoro-1-(2-fluoroethyl)-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid <<3-<1-<(trimethylsilyl)oxy>ethyl>-1-<2-<(2,2-dimethyl-1-oxopropoxy)methoxy>-2-oxo-1-(triphenylphosphoranylidene)etyl>-4-oxo-2-azeti.>> (140928-19-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 63 percent / Et₃N / dimethylformamide / 17 h / Ambient temperature

2: pyridine / 22 h / Ambient temperature

With pyridine; triethylamine; In N,N-dimethyl-formamide;

DOI:10.1021/jm00088a019

Reference yield:

rac-<2R,3S(R)>-2-(3-bromo-2,2-dimethoxypropyl)-3-(1-hydroxyethyl)-4-oxo-α-(triphenylphosphoranylidene)-1-azetidineacetic acid (2,2-dimethyl-1-oxopropyl)methyl ester (138423-44-6) → rac-<2R,3S(R)>-6,8-difluoro-1-(2-fluoroethyl)-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid <<3-<1-<(trimethylsilyl)oxy>ethyl>-1-<2-<(2,2-dimethyl-1-oxopropoxy)methoxy>-2-oxo-1-(triphenylphosphoranylidene)etyl>-4-oxo-2-azeti.>> (140928-19-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 52 percent / 48percent aq. HBr / acetone / 0.33 h / 0 °C

2: 63 percent / Et₃N / dimethylformamide / 17 h / Ambient temperature

3: pyridine / 22 h / Ambient temperature

With pyridine; hydrogen bromide; triethylamine; In N,N-dimethyl-formamide; acetone;

DOI:10.1021/jm00088a019

upstream raw materials:

6,8-difluoro-1-(2-fluoroethyl)-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid potassium salt

rac-<2R,3S(R)>-2-(3-bromo-2-oxopropyl)-3-(1-hydroxyethyl)-4-oxo-α-(triphenylphosphoranylidene)azetidine-1-acetic acid (2,2-dimethyl-1-oxopropoxy)methyl ester

rac-<2R,3S(R)>-2-(3-bromo-2,2-dimethoxypropyl)-3-(1-hydroxyethyl)-4-oxo-α-(triphenylphosphoranylidene)-1-azetidineacetic acid (2,2-dimethyl-1-oxopropyl)methyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 140928-19-4 rac-<2R,3S(R)>-6,8-difluoro-1-(2-fluoroethyl)-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid <<3-<1-<(trimethylsilyl)oxy>ethyl>-1-<2-<(2,2-dimethyl-1-oxopropoxy)methoxy>-2-oxo-1-(triphenylphosphoranylidene)etyl>-4-oxo-2-azeti.>>

Send

Send

Metric Ton KG G Pound L ML

Send

Send