5-chloro-3-(chloromethyl)-1H-indazole

Base Information

Chemical Name:5-chloro-3-(chloromethyl)-1H-indazole
CAS No.:27328-69-4
Molecular Formula:C₈H₆Cl₂N₂
Molecular Weight:201.055
Hs Code.:
DSSTox Substance ID:DTXSID001288021

Synonyms:5-chloro-3-(chloromethyl)-1H-indazole;27328-69-4;5-chloro-3-(chloromethyl)-2H-indazole;1H-Indazole, 5-chloro-3-(chloromethyl)-;SCHEMBL3369543;USFRWHBPXGUKFJ-UHFFFAOYSA-N;DTXSID001288021;3-chloromethyl-5-chloro-1H-indazole;5-chloro-3-chloromethyl-1H-indazole;5-chlor-3-(chlormethyl)-1H-indazol;AKOS027337894;BS-16774;F30642

Suppliers and Price of 5-chloro-3-(chloromethyl)-1H-indazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of 5-chloro-3-(chloromethyl)-1H-indazole

Chemical Property:

XLogP3:2.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:1
Exact Mass:199.9908036
Heavy Atom Count:12
Complexity:165

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC2=NNC(=C2C=C1Cl)CCl

Technology Process of 5-chloro-3-(chloromethyl)-1H-indazole

There total 4 articles about 5-chloro-3-(chloromethyl)-1H-indazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 64605-36-3
5-chloro-2-amino-α-chloroacetophenone

: 27328-69-4
5-chloro-3-(chloromethyl)-1H-indazole

Guidance literature:: 5-chloro-2-amino-α-chloroacetophenone; With hydrogenchloride; sodium nitrite; In water; at 0 ℃; for 1h;

With tin(ll) chloride; In water; at 0 ℃; for 1h;

Reference yield:

: 106-47-8
4-chloro-aniline

: 27328-69-4
5-chloro-3-(chloromethyl)-1H-indazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: boron trichloride; aluminum (III) chloride / toluene / 24 h / 120 °C

1.2: 0.5 h / 80 °C

2.1: hydrogenchloride; sodium nitrite / water / 1 h / -10 °C

2.2: 1 h / -10 °C

With hydrogenchloride; aluminum (III) chloride; boron trichloride; sodium nitrite; In water; toluene;

Reference yield:

: 106-47-8
4-chloro-aniline

: 27328-69-4
5-chloro-3-(chloromethyl)-1H-indazole

Guidance literature:: Multi-step reaction with 2 steps

1: BCl₃, AlCl₃

2: 1.) HCl, NaNO₂, 2.) SnCl₂*2H₂O, HCl / 1.) H₂O, -10 deg C to 0 deg C, 1 h, 2.) 1 h

With hydrogenchloride; aluminium trichloride; boron trichloride; tin(ll) chloride; sodium nitrite;