Cyclopentanecarboxylic acid, 1-(4-iodophenyl)-

Base Information

• Chemical Name: Cyclopentanecarboxylic acid, 1-(4-iodophenyl)-
• CAS No.: 135569-28-7
• Molecular Formula: C12H13IO2
• Molecular Weight: 316.139
• Mol file: 135569-28-7.mol

Synonyms:4-iodophenylcyclopentylcarboxylic acid;1-(p-iodophenyl)cyclopentanecarboxylic acid;

Chemical Property of Cyclopentanecarboxylic acid, 1-(4-iodophenyl)-

Chemical Property:

• PSA: 37.30000
• LogP: 3.18760

Purity/Quality:

97% ^*data from raw suppliers

1-(4-IODOPHENYL)CYCLOPENTANECARBOXYLIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Cyclopentanecarboxylic acid, 1-(4-iodophenyl)-

There total 6 articles about Cyclopentanecarboxylic acid, 1-(4-iodophenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

1-phenyl-1-cyclopentanecarboxylic acid (77-55-4) → 1-(p-iodophenyl)cyclopentanecarboxylic acid (135569-28-7)

Guidance literature:

With sodium iodate; sulfuric acid; iodine; at 20 - 70 ℃; for 72h;

Reference yield:

ethyl 1-(4-iodophenyl)cyclopentanecarboxylate → 1-(p-iodophenyl)cyclopentanecarboxylic acid (135569-28-7)

Guidance literature:

With lithium hydroxide monohydrate; In tetrahydrofuran; methanol; water; at 20 ℃;

Reference yield:

1-phenyl-1-cyclopentanecarboxylic acid (77-55-4) → 1-(p-iodophenyl)cyclopentanecarboxylic acid (135569-28-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 87 percent / HNO₃, H₂SO₄ / 3 h / 0 - 20 °C

2: 76 percent / H₂ / 10percent Pd/C / ethanol / 24 h / 760 Torr / Ambient temperature

3: 1.) NaNO₂, HCl, 2.) KI / 1.) H₂O, 0 deg C, 2.) H₂O, RT, 16 h

With hydrogenchloride; sulfuric acid; hydrogen; nitric acid; potassium iodide; sodium nitrite; palladium on activated charcoal; In ethanol;

DOI:10.1002/(SICI)1099-1344(199605)38:5<471::AID-JLCR854>3.0.CO;2-Q

upstream raw materials:

1-(p-aminophenyl)cyclopentanecarboxylic acid

1-phenyl-1-cyclopentanecarboxylic acid

1-(4-nitro-phenyl)-cyclopentanecarboxylic acid

ethyl (4-iodophenyl)acetate

Downstream raw materials:

Iodocaramiphen