Technology Process of (S)-2-(m-tolyl)-1-octanol
There total 3 articles about (S)-2-(m-tolyl)-1-octanol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium tetrahydroborate;
In
methanol; diethyl ether; toluene;
at -78 ℃;
for 1h;
DOI:10.1021/ja2008906
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane
1.2: 0 - 20 °C
2.1: (2R,5R)-2-tert-butyl-3-methyl-5-phenyl-4-imidazolidinone trichloroacetic acid salt; sodium hydrogencarbonate; copper(I) bromide / diethyl ether; toluene / 3 h / 23 °C / Inert atmosphere
3.1: sodium tetrahydroborate / methanol; diethyl ether; toluene / 1 h / -78 °C
With
sodium tetrahydroborate; (2R,5R)-2-tert-butyl-3-methyl-5-phenyl-4-imidazolidinone trichloroacetic acid salt; sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; copper(I) bromide;
In
methanol; diethyl ether; dichloromethane; toluene;
DOI:10.1021/ja2008906
- Guidance literature:
-
Multi-step reaction with 2 steps
1: (2R,5R)-2-tert-butyl-3-methyl-5-phenyl-4-imidazolidinone trichloroacetic acid salt; sodium hydrogencarbonate; copper(I) bromide / diethyl ether; toluene / 3 h / 23 °C / Inert atmosphere
2: sodium tetrahydroborate / methanol; diethyl ether; toluene / 1 h / -78 °C
With
sodium tetrahydroborate; (2R,5R)-2-tert-butyl-3-methyl-5-phenyl-4-imidazolidinone trichloroacetic acid salt; sodium hydrogencarbonate; copper(I) bromide;
In
methanol; diethyl ether; toluene;
DOI:10.1021/ja2008906
