Technology Process of methyl 3,5-difluoroadamantane-1-carboxylate
There total 1 articles about methyl 3,5-difluoroadamantane-1-carboxylate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
triethylamine pentahydrogen fluoride salt;
at 20 ℃;
Electrochemical reaction;
DOI:10.1021/jo8004759
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium hydroxide / methanol / 4 h / Reflux
2.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 1 h / 20 °C
2.2: 4 h / 20 °C
3.1: lithium aluminium tetrahydride / tetrahydrofuran / 21 h / Reflux
4.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / dichloromethane / 18 h
With
lithium aluminium tetrahydride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; 1,1'-carbonyldiimidazole; sodium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/acschemneuro.7b00272
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: potassium hydroxide; potassium permanganate / water / Reflux
2.1: (bis-(2-methoxyethyl)amino)sulfur trufluoride / chloroform / 2 h / -78 °C / Reflux
3.1: sodium hydroxide / methanol / 4 h / Reflux
4.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 1 h / 20 °C
4.2: 4 h / 20 °C
5.1: lithium aluminium tetrahydride / tetrahydrofuran / 21 h / Reflux
6.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / dichloromethane / 18 h
With
potassium permanganate; lithium aluminium tetrahydride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; 1,1'-carbonyldiimidazole; potassium hydroxide; sodium hydroxide; (bis-(2-methoxyethyl)amino)sulfur trufluoride;
In
tetrahydrofuran; methanol; dichloromethane; chloroform; water;
DOI:10.1021/acschemneuro.7b00272
