(1R,2S,4'R)-{benzyl-2-(tert-butyldimethylsilyloxy)-2-(2',2'-dimethyl-1',3'-dioxolan-4'-yl)-1-(imidazo[1,2-a]pyrimidin-2''-yl-ethyl)}-N-methylethanamine

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Chemical Name:(1R,2S,4'R)-{benzyl-2-(tert-butyldimethylsilyloxy)-2-(2',2'-dimethyl-1',3'-dioxolan-4'-yl)-1-(imidazo[1,2-a]pyrimidin-2''-yl-ethyl)}-N-methylethanamine
CAS No.:1291072-27-9
Molecular Formula:C₂₇H₄₀N₄O₃Si
Molecular Weight:496.725
Hs Code.:

(1R,2S,4'R)-{benzyl-2-(tert-butyldimethylsilyloxy)-2-(2',2'-dimethyl-1',3'-dioxolan-4'-yl)-1-(imidazo[1,2-a]pyrimidin-2''-yl-ethyl)}-N-methylethanamine

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Chemical Property of (1R,2S,4'R)-{benzyl-2-(tert-butyldimethylsilyloxy)-2-(2',2'-dimethyl-1',3'-dioxolan-4'-yl)-1-(imidazo[1,2-a]pyrimidin-2''-yl-ethyl)}-N-methylethanamine

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Technology Process of (1R,2S,4'R)-{benzyl-2-(tert-butyldimethylsilyloxy)-2-(2',2'-dimethyl-1',3'-dioxolan-4'-yl)-1-(imidazo[1,2-a]pyrimidin-2''-yl-ethyl)}-N-methylethanamine

There total 2 articles about (1R,2S,4'R)-{benzyl-2-(tert-butyldimethylsilyloxy)-2-(2',2'-dimethyl-1',3'-dioxolan-4'-yl)-1-(imidazo[1,2-a]pyrimidin-2''-yl-ethyl)}-N-methylethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 2-aminoimidazole hemisulfate

: (4S,5S,4'R)-4-(benzyl(methyl)amino)-5-(tert-butyldimethylsiloxy)-5-(-2',2'-dimethyl-1',3'-dioxolan-4'-yl)-3-[2-(trimethylsilyl)ethoxy]pent-2-enal

: 1291072-27-9
(1R,2S,4'R)-{benzyl-2-(tert-butyldimethylsilyloxy)-2-(2',2'-dimethyl-1',3'-dioxolan-4'-yl)-1-(imidazo[1,2-a]pyrimidin-2''-yl-ethyl)}-N-methylethanamine

Guidance literature:: With sodium acetate; In ethanol; Reflux; Inert atmosphere;
DOI:10.1055/s-0030-1258326

Reference yield:

: 870461-22-6
(3S,1'S,4''R)-2-benzyl-1'-[(tert-butyldimethylsiloxy)-(2'',2''-dimethyl-1'',3''-dioxolan-4''-yl)-methyl]-4-[2'''-(trimethylsilyl)ethoxy]-3,6-dihydro-2H-1,2-oxazine

: 1291072-27-9
(1R,2S,4'R)-{benzyl-2-(tert-butyldimethylsilyloxy)-2-(2',2'-dimethyl-1',3'-dioxolan-4'-yl)-1-(imidazo[1,2-a]pyrimidin-2''-yl-ethyl)}-N-methylethanamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: acetonitrile / 6 h / 0 - 20 °C / Inert atmosphere

1.2: 1 h / 0 °C / Inert atmosphere

2.1: sodium acetate / ethanol / Reflux; Inert atmosphere

With sodium acetate; In ethanol; acetonitrile;
DOI:10.1055/s-0030-1258326