ButanaMide, 2-aMino-N-[(1S,3S,4S)-4-[bis(phenylMethyl)aMino]-3-hydroxy-5-phenyl-1-(phenylMethyl)pentyl]-3-Methyl-, (2S)-

Base Information

Chemical Name:ButanaMide, 2-aMino-N-[(1S,3S,4S)-4-[bis(phenylMethyl)aMino]-3-hydroxy-5-phenyl-1-(phenylMethyl)pentyl]-3-Methyl-, (2S)-
CAS No.:330457-56-2
Molecular Formula:C₃₇H₄₅N₃O₂
Molecular Weight:563.783
Hs Code.:
Mol file:330457-56-2.mol

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ButanaMide, 2-aMino-N-[(1S,3S,4S)-4-[bis(phenylMethyl)aMino]-3-hydroxy-5-phenyl-1-(phenylMethyl)pentyl]-3-Methyl-, (2S)-

Chemical Property:

Boiling Point:761.5±60.0 °C(Predicted)
PKA:14.40±0.20(Predicted)
Density:1.122±0.06 g/cm3(Predicted)

Purity/Quality:

Safty Information:

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Hazard Codes:

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Technology Process of ButanaMide, 2-aMino-N-[(1S,3S,4S)-4-[bis(phenylMethyl)aMino]-3-hydroxy-5-phenyl-1-(phenylMethyl)pentyl]-3-Methyl-, (2S)-

There total 7 articles about ButanaMide, 2-aMino-N-[(1S,3S,4S)-4-[bis(phenylMethyl)aMino]-3-hydroxy-5-phenyl-1-(phenylMethyl)pentyl]-3-Methyl-, (2S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 24601-74-9
(S)-4-isopropyloxazolidine-2,5-dione

: 156732-15-9
(2S,3S,5S)-2-(N,N-dibenzylamino)-3-hydroxy-5-amino-1,6-diphenylhexane

: 330457-56-2
(S)-2-amino-N-[(2S,4S,5S)-5-(dibenzylamino)-4-hydroxy-1,6-diphenylhexan-2-yl]-3-methylbutanamide

Guidance literature:: With triethylamine; In dichloromethane; at -15 ℃; for 4h; Inert atmosphere;
DOI:10.1016/j.bmc.2018.10.001

Reference yield:

: 156732-12-6
(4S)-4-(N,N-dibenzylamino)-3-oxo-5-phenyl-pentanonitrile

: 330457-56-2
(S)-2-amino-N-[(2S,4S,5S)-5-(dibenzylamino)-4-hydroxy-1,6-diphenylhexan-2-yl]-3-methylbutanamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrahydrofuran / 0 - 20 °C

2.1: sodium tetrahydroborate; methanesulfonic acid / tetrahydrofuran; isopropyl alcohol / 0 - 10 °C

2.2: 4.75 h / 0 - 15 °C

3.1: triethylamine / dichloromethane / 4 h / -15 °C / Inert atmosphere

With sodium tetrahydroborate; methanesulfonic acid; triethylamine; In tetrahydrofuran; dichloromethane; isopropyl alcohol;
DOI:10.1016/j.bmc.2018.10.001

Reference yield:

: 156732-13-7
(5S)-2-amino-5-dibenzylamino-4-oxo-1,6-diphenylhex-2-ene

: 330457-56-2
(S)-2-amino-N-[(2S,4S,5S)-5-(dibenzylamino)-4-hydroxy-1,6-diphenylhexan-2-yl]-3-methylbutanamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium tetrahydroborate; methanesulfonic acid / tetrahydrofuran; isopropyl alcohol / 0 - 10 °C

1.2: 4.75 h / 0 - 15 °C

2.1: triethylamine / dichloromethane / 4 h / -15 °C / Inert atmosphere

With sodium tetrahydroborate; methanesulfonic acid; triethylamine; In tetrahydrofuran; dichloromethane; isopropyl alcohol;
DOI:10.1016/j.bmc.2018.10.001