Technology Process of 2-{2-[(R)-3-tert-butoxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)propionylamino]phenylethynyl}benzoic acid
There total 7 articles about 2-{2-[(R)-3-tert-butoxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)propionylamino]phenylethynyl}benzoic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
Jones reagent;
In
acetone;
at 20 ℃;
for 2h;
DOI:10.1021/jo202604q
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: trans-bis(triphenylphosphine)palladium dichloride; triethylamine; triphenylphosphine / tetrahydrofuran / 0.33 h / Inert atmosphere
1.2: 18 h / 20 °C / Inert atmosphere
2.1: piperidine; trans-bis(triphenylphosphine)palladium dichloride; triphenylphosphine / tetrahydrofuran / 0.33 h / Inert atmosphere
2.2: 18 h / Inert atmosphere; Reflux
3.1: silver cyanide / dichloromethane / 2 h / 20 °C / Inert atmosphere; Darkness
4.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.33 h / Inert atmosphere; Cooling with ice
5.1: Jones reagent / acetone / 2 h / 20 °C
With
piperidine; lithium aluminium tetrahydride; Jones reagent; silver cyanide; trans-bis(triphenylphosphine)palladium dichloride; triethylamine; triphenylphosphine;
In
tetrahydrofuran; dichloromethane; acetone;
1.1: Sonogashira coupling / 1.2: Sonogashira coupling / 2.1: Sonogashira coupling / 2.2: Sonogashira coupling;
DOI:10.1021/jo202604q
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sulfuric acid / 2.5 h / Inert atmosphere; Reflux
2.1: trans-bis(triphenylphosphine)palladium dichloride; triethylamine; triphenylphosphine / tetrahydrofuran / 0.33 h / Inert atmosphere
2.2: 18 h / 20 °C / Inert atmosphere
3.1: piperidine; trans-bis(triphenylphosphine)palladium dichloride; triphenylphosphine / tetrahydrofuran / 0.33 h / Inert atmosphere
3.2: 18 h / Inert atmosphere; Reflux
4.1: silver cyanide / dichloromethane / 2 h / 20 °C / Inert atmosphere; Darkness
5.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.33 h / Inert atmosphere; Cooling with ice
6.1: Jones reagent / acetone / 2 h / 20 °C
With
piperidine; lithium aluminium tetrahydride; Jones reagent; silver cyanide; trans-bis(triphenylphosphine)palladium dichloride; sulfuric acid; triethylamine; triphenylphosphine;
In
tetrahydrofuran; dichloromethane; acetone;
2.1: Sonogashira coupling / 2.2: Sonogashira coupling / 3.1: Sonogashira coupling / 3.2: Sonogashira coupling;
DOI:10.1021/jo202604q
