4-(5-Ethyl-1-methyl-4-{3-[5-phenyl-2-(3-phenyl-propyl)-pentylamino]-benzoyl}-1H-pyrrol-2-yl)-butyric acid ethyl ester

Base Information

• Chemical Name: 4-(5-Ethyl-1-methyl-4-{3-[5-phenyl-2-(3-phenyl-propyl)-pentylamino]-benzoyl}-1H-pyrrol-2-yl)-butyric acid ethyl ester
• CAS No.: 199990-05-1
• Molecular Formula: C₄₀H₅₀N₂O₃
• Molecular Weight: 606.849
• Mol file: 199990-05-1.mol

Synonyms:

Chemical Property of 4-(5-Ethyl-1-methyl-4-{3-[5-phenyl-2-(3-phenyl-propyl)-pentylamino]-benzoyl}-1H-pyrrol-2-yl)-butyric acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(5-Ethyl-1-methyl-4-{3-[5-phenyl-2-(3-phenyl-propyl)-pentylamino]-benzoyl}-1H-pyrrol-2-yl)-butyric acid ethyl ester

There total 15 articles about 4-(5-Ethyl-1-methyl-4-{3-[5-phenyl-2-(3-phenyl-propyl)-pentylamino]-benzoyl}-1H-pyrrol-2-yl)-butyric acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-[4-(3-{Benzyloxycarbonyl-[5-phenyl-2-(3-phenyl-propyl)-pentyl]-amino}-benzoyl)-5-ethyl-1-methyl-1H-pyrrol-2-yl]-butyric acid ethyl ester → 4-(5-Ethyl-1-methyl-4-{3-[5-phenyl-2-(3-phenyl-propyl)-pentylamino]-benzoyl}-1H-pyrrol-2-yl)-butyric acid ethyl ester (199990-05-1)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol;

DOI:10.1248/cpb.45.1767

Reference yield:

2-ethyl-1H-pyrrole (1551-06-0) → 4-(5-Ethyl-1-methyl-4-{3-[5-phenyl-2-(3-phenyl-propyl)-pentylamino]-benzoyl}-1H-pyrrol-2-yl)-butyric acid ethyl ester (199990-05-1)

Guidance literature:

Multi-step reaction with 9 steps

1: 1.) oxalyl chloride, 3.) AlCl₃

2: K₂CO₃ / dimethylformamide / 1 h / Ambient temperature

3: 1.) potassium tert-butoxide / 1.) THF, 0 deg C, 20 min, 2.) THF, RT, 20 min

4: HCl / tetrahydrofuran; dioxane / 0.5 h

5: dimethylformamide / 1.5 h / Ambient temperature

6: H₂ / 10percent Pd/C / ethanol / 0.5 h / 1471.02 Torr

7: 20.3 percent / N,N-diisopropylethylamine / CH₂Cl₂ / 1.5 h / Ambient temperature

8: NaH / dimethylformamide / 24 h / Ambient temperature

9: H₂ / 10percent Pd/C / ethanol

With hydrogenchloride; aluminium trichloride; oxalyl dichloride; potassium tert-butylate; hydrogen; sodium hydride; potassium carbonate; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1248/cpb.45.1767

Reference yield:

1.7-Diphenylheptan-4-one (63434-46-8) → 4-(5-Ethyl-1-methyl-4-{3-[5-phenyl-2-(3-phenyl-propyl)-pentylamino]-benzoyl}-1H-pyrrol-2-yl)-butyric acid ethyl ester (199990-05-1)

Guidance literature:

Multi-step reaction with 6 steps

1: 1.) potassium tert-butoxide / 1.) THF, 0 deg C, 30 min, 2.) THF, RT, 1 h

2: HCl / tetrahydrofuran; dioxane

3: NaBH₄ / methanol

4: CBr₄, Ph₃P / tetrahydrofuran / 0.5 h / Ambient temperature

5: NaH / dimethylformamide / 24 h / Ambient temperature

6: H₂ / 10percent Pd/C / ethanol

With hydrogenchloride; sodium tetrahydroborate; carbon tetrabromide; potassium tert-butylate; hydrogen; sodium hydride; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; N,N-dimethyl-formamide;

DOI:10.1248/cpb.45.1767

upstream raw materials:

2-ethyl-1H-pyrrole

1.7-Diphenylheptan-4-one

5-phenyl-2-(3-phenylpropyl)pentan-1-al

m-nitrobenzoic acid chloride