3-{[tert-Butyl(dimethyl)silyl]oxy}-4-methylbenzoic acid

Base Information

Chemical Name:3-{[tert-Butyl(dimethyl)silyl]oxy}-4-methylbenzoic acid
CAS No.:135865-51-9
Molecular Formula:C₁₄H₂₂O₃Si
Molecular Weight:266.412
Hs Code.:
DSSTox Substance ID:DTXSID00711407
Wikidata:Q82647044

Synonyms:135865-51-9;3-((tert-Butyldimethylsilyl)oxy)-4-methylbenzoic acid;3-[(TERT-BUTYLDIMETHYLSILYL)OXY]-4-METHYLBENZOIC ACID;SCHEMBL8696286;3-{[tert-Butyl(dimethyl)silyl]oxy}-4-methylbenzoic acid;DTXSID00711407;EN300-33311903

Suppliers and Price of 3-{[tert-Butyl(dimethyl)silyl]oxy}-4-methylbenzoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 3-{[tert-Butyl(dimethyl)silyl]oxy}-4-methylbenzoic acid

Chemical Property:

Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:266.13382109
Heavy Atom Count:18
Complexity:307

Purity/Quality:: 98%min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(C=C(C=C1)C(=O)O)O[Si](C)(C)C(C)(C)C

Technology Process of 3-{[tert-Butyl(dimethyl)silyl]oxy}-4-methylbenzoic acid

There total 1 articles about 3-{[tert-Butyl(dimethyl)silyl]oxy}-4-methylbenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 586-30-1
3-hydroxy-4-methylbenzoic acid

: 69739-34-0
t-butyldimethylsiyl triflate

: 135865-51-9
3-(tert-butyl-dimethyl-silanyloxy)-4-methyl-benzoic acid

Guidance literature:: With triethylamine;
DOI:10.1016/j.bmcl.2004.01.102

Reference yield:

: 135865-51-9
3-(tert-butyl-dimethyl-silanyloxy)-4-methyl-benzoic acid

: 3-[3-(tert-butyl-dimethyl-silanyloxy)-4-methyl-phenyl]-propan-1-ol

Guidance literature:: Multi-step reaction with 5 steps

1.1: diisobutylaluminum hydride

2.1: TPAP; N-methylmorpholine oxide

3.1: H₂ / Pd/C

3.2: diisobutylaluminum hydride

With tetrapropylammonium perruthennate; hydrogen; diisobutylaluminium hydride; 4-methylmorpholine N-oxide; palladium on activated charcoal;
DOI:10.1016/j.bmcl.2004.01.102

Reference yield:

: 135865-51-9
3-(tert-butyl-dimethyl-silanyloxy)-4-methyl-benzoic acid

: 3-[3-(tert-butyl-dimethyl-silanyloxy)-4-methyl-phenyl]-acrylic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: diisobutylaluminum hydride

2: TPAP; N-methylmorpholine oxide

With tetrapropylammonium perruthennate; diisobutylaluminium hydride; 4-methylmorpholine N-oxide;
DOI:10.1016/j.bmcl.2004.01.102