Technology Process of 2-[4-(mopholinomethyl)phenyl]benzofuran-7-carboxamide
There total 7 articles about 2-[4-(mopholinomethyl)phenyl]benzofuran-7-carboxamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 8 h / 120 °C
2.1: sodium hydroxide / methanol / 1 h / Reflux
2.2: 20 °C
3.1: acetic acid / 1,2-dichloro-ethane / 2 h / 20 °C
3.2: 8 h / 20 °C
4.1: thionyl chloride / 1,2-dichloro-ethane / 3 h / 20 °C
5.1: ammonium hydroxide / tetrahydrofuran; water / 1 h / 0 - 20 °C
With
ammonium hydroxide; thionyl chloride; potassium carbonate; acetic acid; sodium hydroxide;
In
tetrahydrofuran; methanol; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.5012/bkcs.2012.33.4.1147
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 3 h / Reflux
2.1: water; silver nitrate / ethanol / 0.25 h / 100 °C / Reflux
3.1: potassium carbonate / N,N-dimethyl-formamide / 8 h / 120 °C
4.1: sodium hydroxide / methanol / 1 h / Reflux
4.2: 20 °C
5.1: acetic acid / 1,2-dichloro-ethane / 2 h / 20 °C
5.2: 8 h / 20 °C
6.1: thionyl chloride / 1,2-dichloro-ethane / 3 h / 20 °C
7.1: ammonium hydroxide / tetrahydrofuran; water / 1 h / 0 - 20 °C
With
ammonium hydroxide; N-Bromosuccinimide; thionyl chloride; 2,2'-azobis(isobutyronitrile); water; potassium carbonate; silver nitrate; acetic acid; sodium hydroxide;
In
tetrahydrofuran; methanol; tetrachloromethane; ethanol; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.5012/bkcs.2012.33.4.1147
