cyclopropyl(trimethylsilyl)methanol

Base Information

• Chemical Name: cyclopropyl(trimethylsilyl)methanol
• CAS No.: 114551-27-8
• Molecular Formula: C₇H₁₆OSi
• Molecular Weight: 144.289
• Mol file: 114551-27-8.mol

Synonyms:

Chemical Property of cyclopropyl(trimethylsilyl)methanol

Chemical Property:

Purity/Quality:

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Technology Process of cyclopropyl(trimethylsilyl)methanol

There total 1 articles about cyclopropyl(trimethylsilyl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

((trimethylsilyl)oxy)(cyclopropylmethyl)(CH)tributylstannane (114551-40-5) → Z-(1-buten-1-yloxy)trimethylsilane (19980-22-4) + cyclopropyl(trimethylsilyl)methanol (114551-27-8)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; byproducts: Sn(n-Bu)4; disoln. of stannyl silyl ether in dry THF, cooling to -78°C (under Ar), dropwise addn. of n-BuLi in hexane (3 equiv.) (via syringe), stirring (-78°C, 15 min), quenching by rapid addn. of water at -78°C; warming to room temp., extn. with petroleum ether, flash chromy., elution of tetraalkylstannane with hexane, eluation of product with ethyl acetate/hexane, GC/MS, NMR;

DOI:10.1021/ja00162a048

upstream raw materials:

((trimethylsilyl)oxy)(cyclopropylmethyl)(CH)tributylstannane