Technology Process of 2'-fluorofolic acid
There total 5 articles about 2'-fluorofolic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine / dichloromethane / 18 h / 20 °C / Inert atmosphere
2: dichloromethane / 0 - 20 °C / Inert atmosphere
3: N,N-dimethyl acetamide / 6 h / 60 °C / Inert atmosphere
With
O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine;
In
dichloromethane; N,N-dimethyl acetamide;
DOI:10.1055/s-0030-1260247
- Guidance literature:
-
Multi-step reaction with 4 steps
1: sodium hydroxide / 1,4-dioxane; water / 48 h / 20 °C / Inert atmosphere
2: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine / dichloromethane / 18 h / 20 °C / Inert atmosphere
3: dichloromethane / 0 - 20 °C / Inert atmosphere
4: N,N-dimethyl acetamide / 6 h / 60 °C / Inert atmosphere
With
O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; sodium hydroxide;
In
1,4-dioxane; dichloromethane; N,N-dimethyl acetamide; water;
DOI:10.1055/s-0030-1260247
- Guidance literature:
-
Multi-step reaction with 2 steps
1: dichloromethane / 0 - 20 °C / Inert atmosphere
2: N,N-dimethyl acetamide / 6 h / 60 °C / Inert atmosphere
In
dichloromethane; N,N-dimethyl acetamide;
DOI:10.1055/s-0030-1260247
