(4R)-4-{1S-[1-(tert-butoxycarbonyl-2-methylpropyl)carbamoyl]-2-O-tert-butyldiphenylsilyloxy}ethyl-2-(2,2,2-trichloroethoxysulfonyl)iminotetrahydropyrimidine

Base Information

• Chemical Name: (4R)-4-{1S-[1-(tert-butoxycarbonyl-2-methylpropyl)carbamoyl]-2-O-tert-butyldiphenylsilyloxy}ethyl-2-(2,2,2-trichloroethoxysulfonyl)iminotetrahydropyrimidine
• CAS No.: 1211774-26-3
• Molecular Formula: C₃₄H₅₀Cl₃N₅O₇SSi
• Molecular Weight: 807.311

Synonyms:

Chemical Property of (4R)-4-{1S-[1-(tert-butoxycarbonyl-2-methylpropyl)carbamoyl]-2-O-tert-butyldiphenylsilyloxy}ethyl-2-(2,2,2-trichloroethoxysulfonyl)iminotetrahydropyrimidine

Chemical Property:

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Technology Process of (4R)-4-{1S-[1-(tert-butoxycarbonyl-2-methylpropyl)carbamoyl]-2-O-tert-butyldiphenylsilyloxy}ethyl-2-(2,2,2-trichloroethoxysulfonyl)iminotetrahydropyrimidine

There total 2 articles about (4R)-4-{1S-[1-(tert-butoxycarbonyl-2-methylpropyl)carbamoyl]-2-O-tert-butyldiphenylsilyloxy}ethyl-2-(2,2,2-trichloroethoxysulfonyl)iminotetrahydropyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

tert-butyl L-valinate (13211-31-9) + bis(trichloromethyl) carbonate (32315-10-9) + (4R)-4-(1S-amino-2-O-tert-butyldiphenylsilyloxy)ethyl-2-(2,2,2-trichloroethoxysulfonyl)iminotetrahydropyrimidine (1211774-19-4) → (4R)-4-{1S-[1-(tert-butoxycarbonyl-2-methylpropyl)carbamoyl]-2-O-tert-butyldiphenylsilyloxy}ethyl-2-(2,2,2-trichloroethoxysulfonyl)iminotetrahydropyrimidine (1211774-26-3)

Guidance literature:

With triethylamine; In dichloromethane;

DOI:10.1021/jo9027193

Reference yield:

tert-butyl L-valinate (13211-31-9) + (4R)-4-(1S-amino-2-O-tert-butyldiphenylsilyloxy)ethyl-2-(2,2,2-trichloroethoxysulfonyl)iminotetrahydropyrimidine (1211774-19-4) → (4R)-4-{1S-[1-(tert-butoxycarbonyl-2-methylpropyl)carbamoyl]-2-O-tert-butyldiphenylsilyloxy}ethyl-2-(2,2,2-trichloroethoxysulfonyl)iminotetrahydropyrimidine + (4R)-4-{1S-[1-(tert-butoxycarbonyl-2-methylpropyl)carbamoyl]-2-O-tert-butyldiphenylsilyloxy}ethyl-2-(2,2,2-trichloroethoxysulfonyl)iminotetrahydropyrimidine (1211774-26-3)

Guidance literature:

With dmap; 1,1'-carbonyldiimidazole; In dichloromethane;

DOI:10.1021/jo9027193

upstream raw materials:

tert-butyl L-valinate

(4R)-4-(1S-amino-2-O-tert-butyldiphenylsilyloxy)ethyl-2-(2,2,2-trichloroethoxysulfonyl)iminotetrahydropyrimidine

bis(trichloromethyl) carbonate

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