AKOS B013900

Base Information

• Chemical Name: AKOS B013900
• CAS No.: 161790-15-4
• Molecular Formula: C₁₀H₁₁FO₃
• Molecular Weight: 198.194
• Mol file: 161790-15-4.mol

Synonyms:

Chemical Property of AKOS B013900

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

2-(4-fluorophenoxy)butanoicAcid ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

Useful:

Technology Process of AKOS B013900

There total 2 articles about AKOS B013900 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-Fluorophenol (371-41-5) + 2-Bromobutyric acid (80-58-0) → 2-(4-fluorophenoxy)butyric acid (161790-15-4)

Guidance literature:

With sodium hydroxide; In ethanol; for 24h; Heating;

DOI:10.1021/jm00037a023

Reference yield:

→ 2-(4-fluorophenoxy)butyric acid (161790-15-4)

Guidance literature:

4-Fluor-phenol, 2-Brom-buttersaeure, wss. NaOH;

Reference yield:

2-(4-fluorophenoxy)butyric acid (161790-15-4) → 2-(4-Fluoro-phenoxy)-butyric acid (1R,3R,5S)-8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl ester

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂ / 1 h / Heating

2: Na₂CO₃ / CH₂Cl₂ / 12 h

With thionyl chloride; sodium carbonate; In dichloromethane;

DOI:10.1021/jm00037a023

upstream raw materials:

4-Fluorophenol

2-Bromobutyric acid

Downstream raw materials:

2-(4-Fluoro-phenoxy)-butyryl chloride

Refernces