2-[2,6-bis-(8-methoxycarbonyloxy-2,4-dioxo-4H-benzo[e][1,3]oxazin-3-yl)-hexanoylamino]-6-(8-methoxycarbonyloxy-2,4-dioxo-4H-benzo[e][1,3]oxazin-3-yl)-hexanoic acid benzyl ester

Base Information

Chemical Name:2-[2,6-bis-(8-methoxycarbonyloxy-2,4-dioxo-4H-benzo[e][1,3]oxazin-3-yl)-hexanoylamino]-6-(8-methoxycarbonyloxy-2,4-dioxo-4H-benzo[e][1,3]oxazin-3-yl)-hexanoic acid benzyl ester
CAS No.:212777-42-9
Molecular Formula:C₄₉H₄₄N₄O₂₁
Molecular Weight:1024.9
Hs Code.:

2-[2,6-bis-(8-methoxycarbonyloxy-2,4-dioxo-4<i>H</i>-benzo[<i>e</i>][1,3]oxazin-3-yl)-hexanoylamino]-6-(8-methoxycarbonyloxy-2,4-dioxo-4<i>H</i>-benzo[<i>e</i>][1,3]oxazin-3-yl)-hexanoic acid benzyl ester

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Chemical Property of 2-[2,6-bis-(8-methoxycarbonyloxy-2,4-dioxo-4H-benzo[e][1,3]oxazin-3-yl)-hexanoylamino]-6-(8-methoxycarbonyloxy-2,4-dioxo-4H-benzo[e][1,3]oxazin-3-yl)-hexanoic acid benzyl ester

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Technology Process of 2-[2,6-bis-(8-methoxycarbonyloxy-2,4-dioxo-4H-benzo[e][1,3]oxazin-3-yl)-hexanoylamino]-6-(8-methoxycarbonyloxy-2,4-dioxo-4H-benzo[e][1,3]oxazin-3-yl)-hexanoic acid benzyl ester

There total 1 articles about 2-[2,6-bis-(8-methoxycarbonyloxy-2,4-dioxo-4H-benzo[e][1,3]oxazin-3-yl)-hexanoylamino]-6-(8-methoxycarbonyloxy-2,4-dioxo-4H-benzo[e][1,3]oxazin-3-yl)-hexanoic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 14.0%

: 201296-89-1
(2,3-dimethoxycarbonyloxy)benzoyl chloride

: N²-L-lysyl-L-lysine benzyl ester tritosylate

: 212777-42-9
2-[2,6-bis-(8-methoxycarbonyloxy-2,4-dioxo-4H-benzo[e][1,3]oxazin-3-yl)-hexanoylamino]-6-(8-methoxycarbonyloxy-2,4-dioxo-4H-benzo[e][1,3]oxazin-3-yl)-hexanoic acid benzyl ester

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃;
DOI:10.1016/S0968-0896(02)00044-5

Reference yield:

: 212777-42-9
2-[2,6-bis-(8-methoxycarbonyloxy-2,4-dioxo-4H-benzo[e][1,3]oxazin-3-yl)-hexanoylamino]-6-(8-methoxycarbonyloxy-2,4-dioxo-4H-benzo[e][1,3]oxazin-3-yl)-hexanoic acid benzyl ester

: N-{2L-[2'L,6'-bis(8-methoxycarbonyloxy-3,4-dihydro-2,4-dioxo-1,3-benzoxazin-3-yl)-n-hexanoylamino]-6-(8-methoxycarbonyloxy-3,4-dihydro-2,4-dioxo-1,3-benzoxazin-3-yl)-n-hexanoyl}-cefaclor

Guidance literature:: Multi-step reaction with 2 steps

1.1: 98 percent / H₂ / 10 percent Pd/C / ethanol / 20 °C / atmospheric pressure

2.1: i-BuOCOCl; N-methylmorpholine / tetrahydrofuran / 0.75 h / -10 °C

2.2: 66 percent / Et₃N / tetrahydrofuran / 2 h / -10 - 20 °C

With 4-methyl-morpholine; hydrogen; isobutyl chloroformate; palladium on activated charcoal; In tetrahydrofuran; ethanol;
DOI:10.1016/S0968-0896(02)00044-5

Reference yield:

: 212777-42-9
2-[2,6-bis-(8-methoxycarbonyloxy-2,4-dioxo-4H-benzo[e][1,3]oxazin-3-yl)-hexanoylamino]-6-(8-methoxycarbonyloxy-2,4-dioxo-4H-benzo[e][1,3]oxazin-3-yl)-hexanoic acid benzyl ester

: N-{2L-[2'L,6'-bis(8-methoxycarbonyloxy-3,4-dihydro-2,4-dioxo-1,3-benzoxazin-3-yl)-n-hexanoylamino]-6-(8-methoxycarbonyloxy-3,4-dihydro-2,4-dioxo-1,3-benzoxazin-3-yl)-n-hexanoyl}-amoxillin

Guidance literature:: Multi-step reaction with 2 steps

1.1: 98 percent / H₂ / 10 percent Pd/C / ethanol / 20 °C / atmospheric pressure

2.1: i-BuOCOCl; N-methylmorpholine / tetrahydrofuran / 0.75 h / -10 °C

2.2: 50 percent / Et₃N / tetrahydrofuran / 2 h / -10 - 20 °C

With 4-methyl-morpholine; hydrogen; isobutyl chloroformate; palladium on activated charcoal; In tetrahydrofuran; ethanol;
DOI:10.1016/S0968-0896(02)00044-5