1-(Biphenyl-2-yl)ethanol

Base Information

• Chemical Name: 1-(Biphenyl-2-yl)ethanol
• CAS No.: 16927-84-7
• Molecular Formula: C14H14 O
• Molecular Weight: 198.265
• NSC Number: 99380
• DSSTox Substance ID: DTXSID50295040
• Nikkaji Number: J408.813A
• Mol file: 16927-84-7.mol

Synonyms:1-(biphenyl-2-yl)ethanol;16927-84-7;1-(2-phenylphenyl)ethan-1-ol;1-(2-phenylphenyl)ethanol;1-([1,1'-Biphenyl]-2-yl)ethanol;NSC99380;SCHEMBL2647486;DTXSID50295040;MFCD15209649;NSC-99380;AKOS022505844;SB85275;1-{[1,1'-biphenyl]-2-yl}ethan-1-ol;EN300-60904;F84506;Z957333472

Chemical Property of 1-(Biphenyl-2-yl)ethanol

Chemical Property:

• Vapor Pressure: 1.6E-05mmHg at 25°C
• Boiling Point: 350.8°C at 760 mmHg
• Flash Point: 154.7°C
• Density: 1.067g/cm³
• XLogP3: 3.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 198.104465066
• Heavy Atom Count: 15
• Complexity: 184

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C1=CC=CC=C1C2=CC=CC=C2)O

Technology Process of 1-(Biphenyl-2-yl)ethanol

There total 4 articles about 1-(Biphenyl-2-yl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

[1-(2-bromophenyl)ethoxy]triphenylsilane (265671-40-7) → 1-(2-bromophenyl)ethanol (5411-56-3) + α-methyl[1,1'-biphenyl]-2-methanol (16927-84-7)

Guidance literature:

[1-(2-bromophenyl)ethoxy]triphenylsilane; With azobisisobutyronitrile; tri-n-butyl-tin hydride; In benzene; for 7.5h;

With methyllithium; In benzene; Further stages.;

DOI:10.1021/ol005661f

Reference yield: 55.0%

methyllithium (917-54-4) + [1-(2-bromophenyl)ethoxy]diphenyl(trimethylsilyl)silane (265671-35-0) → α-methyl[1,1'-biphenyl]-2-methanol (16927-84-7) + [2-(1-hydroxyethyl)phenyl]diphenylmethylsilane

Guidance literature:

[1-(2-bromophenyl)ethoxy]diphenyl(trimethylsilyl)silane; With azobisisobutyronitrile; tri-n-butyl-tin hydride; In benzene; for 7.5h;

methyllithium; In benzene; at 20 ℃; for 12h; Further stages. Title compound not separated from byproducts.;

DOI:10.1021/ol005661f

Reference yield: 52.0%

methyllithium (917-54-4) + ([1-(2-bromophenyl)ethoxy]diphenylsilyl)trimethylgermane → α-methyl[1,1'-biphenyl]-2-methanol (16927-84-7) + [2-(1-hydroxyethyl)phenyl]diphenylmethylsilane

Guidance literature:

([1-(2-bromophenyl)ethoxy]diphenylsilyl)trimethylgermane; With azobisisobutyronitrile; tri-n-butyl-tin hydride; In benzene; for 7.5h;

methyllithium; In benzene; at 20 ℃; for 12h; Further stages. Title compound not separated from byproducts.;

DOI:10.1021/ol005661f

upstream raw materials:

methyllithium

[1-(2-bromophenyl)ethoxy]diphenyl(trimethylsilyl)silane

[1-(2-bromophenyl)ethoxy]triphenylsilane

Downstream raw materials:

2-fluorobiphenyl