Technology Process of 2-(2-(benzofuran-2-yl)ethyl)-6-bromophenol
There total 7 articles about 2-(2-(benzofuran-2-yl)ethyl)-6-bromophenol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
indium(III) chloride;
In
dichloromethane;
at 20 ℃;
for 3h;
Inert atmosphere;
DOI:10.1039/c3ob41065j
- Guidance literature:
-
With
triethylamine tris(hydrogen fluoride);
In
acetonitrile;
at 20 ℃;
for 72h;
Inert atmosphere;
DOI:10.1039/c3ob41065j
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: diisopropylamine; N-Bromosuccinimide / dichloromethane / 20 °C / Inert atmosphere
2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 20 °C / Inert atmosphere
3.1: sodium hydride / tetrahydrofuran; paraffin oil / 0.5 h / 0 - 20 °C / Inert atmosphere
3.2: 18 h / 20 °C / Inert atmosphere
4.1: hydrogen; palladium 10% on activated carbon / ethyl acetate / 25 °C / 22502.3 Torr / Inert atmosphere
5.1: camphor-10-sulfonic acid / tetrahydrofuran; methanol; water / 22 h / 20 °C / Inert atmosphere
6.1: triethylamine tris(hydrogen fluoride) / acetonitrile / 72 h / 20 °C / Inert atmosphere
With
N-Bromosuccinimide; palladium 10% on activated carbon; camphor-10-sulfonic acid; hydrogen; sodium hydride; triethylamine tris(hydrogen fluoride); diisopropylamine; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; acetonitrile; paraffin oil;
3.1: |Horner-Wadsworth-Emmons Olefination / 3.2: |Horner-Wadsworth-Emmons Olefination;
DOI:10.1039/c3ob41065j
