Technology Process of ethyl 1-benzyl-2,5-dioxo-4-piperidineacetate
There total 6 articles about ethyl 1-benzyl-2,5-dioxo-4-piperidineacetate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 80 percent / sodium, ethanol / dioxane / 7 h / Heating
2: 74 percent / 6 h / 170 °C
3: 80 percent / anhydrous potassium carbonate / tetrahydrofuran / 96 h / Ambient temperature
4: 1.) H2 / 1.) 10percent palladium on charcoal / 1.) ethyl acetate, rt; 2.) reflux, 2 h
With
ethanol; hydrogen; sodium; potassium carbonate;
palladium on activated charcoal;
In
tetrahydrofuran; 1,4-dioxane;
DOI:10.1016/S0040-4020(01)83502-X
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 85 percent / 15percent potassium carbonate / benzene; H2O / 10 - 25 °C
2: 80 percent / sodium, ethanol / dioxane / 7 h / Heating
3: 74 percent / 6 h / 170 °C
4: 80 percent / anhydrous potassium carbonate / tetrahydrofuran / 96 h / Ambient temperature
5: 1.) H2 / 1.) 10percent palladium on charcoal / 1.) ethyl acetate, rt; 2.) reflux, 2 h
With
ethanol; hydrogen; sodium; potassium carbonate;
palladium on activated charcoal;
In
tetrahydrofuran; 1,4-dioxane; water; benzene;
DOI:10.1016/S0040-4020(01)83502-X
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 74 percent / 6 h / 170 °C
2: 80 percent / anhydrous potassium carbonate / tetrahydrofuran / 96 h / Ambient temperature
3: 1.) H2 / 1.) 10percent palladium on charcoal / 1.) ethyl acetate, rt; 2.) reflux, 2 h
With
hydrogen; potassium carbonate;
palladium on activated charcoal;
In
tetrahydrofuran;
DOI:10.1016/S0040-4020(01)83502-X
