{(2R,3S)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-2-yl}-thioacetic acid S-((S)-1-{1-[(Z)-4-nitro-benzyloxycarbonylimino]-ethyl}-pyrrolidin-3-yl) ester

Base Information

Chemical Name:{(2R,3S)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-2-yl}-thioacetic acid S-((S)-1-{1-[(Z)-4-nitro-benzyloxycarbonylimino]-ethyl}-pyrrolidin-3-yl) ester
CAS No.:98167-65-8
Molecular Formula:C₂₇H₄₀N₄O₇SSi
Molecular Weight:592.789
Hs Code.:

{(2R,3S)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-2-yl}-thioacetic acid S-((S)-1-{1-[(Z)-4-nitro-benzyloxycarbonylimino]-ethyl}-pyrrolidin-3-yl) ester

Synonyms:

Suppliers and Price of {(2R,3S)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-2-yl}-thioacetic acid S-((S)-1-{1-[(Z)-4-nitro-benzyloxycarbonylimino]-ethyl}-pyrrolidin-3-yl) ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of {(2R,3S)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-2-yl}-thioacetic acid S-((S)-1-{1-[(Z)-4-nitro-benzyloxycarbonylimino]-ethyl}-pyrrolidin-3-yl) ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of {(2R,3S)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-2-yl}-thioacetic acid S-((S)-1-{1-[(Z)-4-nitro-benzyloxycarbonylimino]-ethyl}-pyrrolidin-3-yl) ester

There total 5 articles about {(2R,3S)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-2-yl}-thioacetic acid S-((S)-1-{1-[(Z)-4-nitro-benzyloxycarbonylimino]-ethyl}-pyrrolidin-3-yl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 76899-07-5,78963-47-0,78963-48-1,78963-60-7,80951-41-3,81275-02-7,85647-75-2,85954-95-6,92217-74-8,104527-11-9,76855-69-1
(3R,4R)-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]-4-acetoxyazetidin-2-one

: 98167-65-8
{(2R,3S)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-2-yl}-thioacetic acid S-((S)-1-{1-[(Z)-4-nitro-benzyloxycarbonylimino]-ethyl}-pyrrolidin-3-yl) ester

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / Et₃N / tetrahydrofuran / 2 h / Ambient temperature

2: trimethylsilyl trifluoromethanesulfonate / CH₂Cl₂ / Ambient temperature; overnight

3: 91 percent / pyridinium p-toluenesulfonate / tetrahydrofuran; H₂O / 0.5 h / Ambient temperature

4: 100 percent / H₂ / 10percent Pd-C / methanol

5: N,N'-dicyclohexylcarbodiimide / 4-(N,N-dimethylamino)pyridine / benzene

With hydrogen; triethylamine; dicyclohexyl-carbodiimide; dmap; palladium on activated charcoal; trimethylsilyl trifluoromethanesulfonate; pyridinium p-toluenesulfonate; In tetrahydrofuran; methanol; dichloromethane; water; benzene;
DOI:10.1016/S0040-4039(01)81292-2

Reference yield:

: 87392-18-5
<3S-<3α(S^*),4β>>-benzyl<3-(1-t-butyldimethylsilyloxyethyl)-2-azetidinone-4-yl>acetate

: 98167-65-8
{(2R,3S)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-2-yl}-thioacetic acid S-((S)-1-{1-[(Z)-4-nitro-benzyloxycarbonylimino]-ethyl}-pyrrolidin-3-yl) ester

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / H₂ / 10percent Pd-C / methanol

2: N,N'-dicyclohexylcarbodiimide / 4-(N,N-dimethylamino)pyridine / benzene

With hydrogen; dicyclohexyl-carbodiimide; dmap; palladium on activated charcoal; In methanol; benzene;
DOI:10.1016/S0040-4039(01)81292-2

Reference yield:

: {(2R,3S)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-1-trimethylsilanyl-azetidin-2-yl}-acetic acid benzyl ester

: 98167-65-8
{(2R,3S)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-2-yl}-thioacetic acid S-((S)-1-{1-[(Z)-4-nitro-benzyloxycarbonylimino]-ethyl}-pyrrolidin-3-yl) ester

Guidance literature:: Multi-step reaction with 3 steps

1: 91 percent / pyridinium p-toluenesulfonate / tetrahydrofuran; H₂O / 0.5 h / Ambient temperature

2: 100 percent / H₂ / 10percent Pd-C / methanol

3: N,N'-dicyclohexylcarbodiimide / 4-(N,N-dimethylamino)pyridine / benzene

With hydrogen; dicyclohexyl-carbodiimide; dmap; palladium on activated charcoal; pyridinium p-toluenesulfonate; In tetrahydrofuran; methanol; water; benzene;
DOI:10.1016/S0040-4039(01)81292-2