2,5-dimethoxy-6-methylaniline

Base Information

• Chemical Name: 2,5-dimethoxy-6-methylaniline
• CAS No.: 102438-97-1
• Molecular Formula: C₉H₁₃NO₂
• Molecular Weight: 167.208
• Mol file: 102438-97-1.mol

Synonyms:

Chemical Property of 2,5-dimethoxy-6-methylaniline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,5-dimethoxy-6-methylaniline

There total 2 articles about 2,5-dimethoxy-6-methylaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,6-dimethoxy-2-nitro-toluene (102871-27-2) → 2,5-dimethoxy-6-methylaniline (102438-97-1)

Guidance literature:

With diethyl ether; nickel; at 20 - 25 ℃; under 73550.8 Torr;

Reference yield:

2-methyl-3-nitro-hydroquinone (89791-94-6) → 2,5-dimethoxy-6-methylaniline (102438-97-1)

Guidance literature:

Multi-step reaction with 2 steps

1: aqueous KOH

2: Raney nickel; diethyl ether / 20 - 25 °C / 73550.8 Torr

With potassium hydroxide; diethyl ether; nickel;

Reference yield:

2,5-dimethoxy-6-methylaniline (102438-97-1) → 2-acetyl-3-methyl-1,4-benzoquinone (78606-28-7)

Guidance literature:

Multi-step reaction with 5 steps

1: 1) NaNO₂, H₂SO₄, 2) KBr, HBr, CuBr / 1) water, less than 10 deg C, 2) 90-100 deg C, 0.5 h

2: 1) n-BuLi / 1) hexane, ether, -70 deg C, 1.5 h, 2) -70 deg C, 2.5 h

3: 94 percent / MnO₂ / diethyl ether / 24 h / Heating

4: 74 percent / AlCl₃ / chlorobenzene / 4 h / Heating

5: 94 percent / Ag₂O, Na₂SO₄ / benzene / 2.5 h / Ambient temperature

With manganese(IV) oxide; n-butyllithium; aluminium trichloride; sulfuric acid; hydrogen bromide; sodium sulfate; potassium bromide; copper(I) bromide; silver(l) oxide; sodium nitrite; In diethyl ether; chlorobenzene; benzene;

DOI:10.1080/00397919608003486

upstream raw materials:

3,6-dimethoxy-2-nitro-toluene

2-methyl-3-nitro-hydroquinone

Downstream raw materials:

2-bromo-1,4-dimethoxy-3-methylbenzene

2-acetyl-3-methyl-1,4-benzoquinone

2',5'-dihydroxy-6'-methylacetophenone

2',5'-dimethoxy-6'-methylacetophenone