(S)-N-((S)-1-Methoxycarbonyl-2-phenyl-ethyl)-3-{(S)-4-methylsulfanyl-2-[3-methyl-3-(2,4,5-trimethyl-3,6-dioxo-cyclohexa-1,4-dienyl)-butyrylamino]-butyrylamino}-succinamic acid benzyl ester

Base Information

Chemical Name:(S)-N-((S)-1-Methoxycarbonyl-2-phenyl-ethyl)-3-{(S)-4-methylsulfanyl-2-[3-methyl-3-(2,4,5-trimethyl-3,6-dioxo-cyclohexa-1,4-dienyl)-butyrylamino]-butyrylamino}-succinamic acid benzyl ester
CAS No.:154273-29-7
Molecular Formula:C₄₀H₄₉N₃O₉S
Molecular Weight:747.91
Hs Code.:

(S)-N-((S)-1-Methoxycarbonyl-2-phenyl-ethyl)-3-{(S)-4-methylsulfanyl-2-[3-methyl-3-(2,4,5-trimethyl-3,6-dioxo-cyclohexa-1,4-dienyl)-butyrylamino]-butyrylamino}-succinamic acid benzyl ester

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Chemical Property of (S)-N-((S)-1-Methoxycarbonyl-2-phenyl-ethyl)-3-{(S)-4-methylsulfanyl-2-[3-methyl-3-(2,4,5-trimethyl-3,6-dioxo-cyclohexa-1,4-dienyl)-butyrylamino]-butyrylamino}-succinamic acid benzyl ester

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Technology Process of (S)-N-((S)-1-Methoxycarbonyl-2-phenyl-ethyl)-3-{(S)-4-methylsulfanyl-2-[3-methyl-3-(2,4,5-trimethyl-3,6-dioxo-cyclohexa-1,4-dienyl)-butyrylamino]-butyrylamino}-succinamic acid benzyl ester

There total 4 articles about (S)-N-((S)-1-Methoxycarbonyl-2-phenyl-ethyl)-3-{(S)-4-methylsulfanyl-2-[3-methyl-3-(2,4,5-trimethyl-3,6-dioxo-cyclohexa-1,4-dienyl)-butyrylamino]-butyrylamino}-succinamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7524-50-7
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride

: 154273-29-7
(S)-N-((S)-1-Methoxycarbonyl-2-phenyl-ethyl)-3-{(S)-4-methylsulfanyl-2-[3-methyl-3-(2,4,5-trimethyl-3,6-dioxo-cyclohexa-1,4-dienyl)-butyrylamino]-butyrylamino}-succinamic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: NEt₃, ClCOO-i-Bu, N-methylpiperidine / tetrahydrofuran

2: Na₂S₂O₄ / diethyl ether; H₂O / 0.25 h / Ambient temperature

3: ClCOO-i-Bu, N-methylpiperidine / tetrahydrofuran

With N-methylcyclohexylamine; sodium dithionite; triethylamine; isobutyl chloroformate; In tetrahydrofuran; diethyl ether; water;
DOI:10.1016/S0040-4039(00)61583-6

Reference yield:

: (S)-2-[3-Methyl-3-(2,4,5-trimethyl-3,6-dioxo-cyclohexa-1,4-dienyl)-butyrylamino]-succinic acid 4-benzyl ester

: 154273-29-7
(S)-N-((S)-1-Methoxycarbonyl-2-phenyl-ethyl)-3-{(S)-4-methylsulfanyl-2-[3-methyl-3-(2,4,5-trimethyl-3,6-dioxo-cyclohexa-1,4-dienyl)-butyrylamino]-butyrylamino}-succinamic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: NEt₃, ClCOO-i-Bu, N-methylpiperidine / tetrahydrofuran

2: Na₂S₂O₄ / diethyl ether; H₂O / 0.25 h / Ambient temperature

3: ClCOO-i-Bu, N-methylpiperidine / tetrahydrofuran

With N-methylcyclohexylamine; sodium dithionite; triethylamine; isobutyl chloroformate; In tetrahydrofuran; diethyl ether; water;
DOI:10.1016/S0040-4039(00)61583-6

Reference yield:

: 154273-28-6
(S)-N-((S)-1-Methoxycarbonyl-2-phenyl-ethyl)-3-[3-methyl-3-(2,4,5-trimethyl-3,6-dioxo-cyclohexa-1,4-dienyl)-butyrylamino]-succinamic acid benzyl ester

: 154273-29-7
(S)-N-((S)-1-Methoxycarbonyl-2-phenyl-ethyl)-3-{(S)-4-methylsulfanyl-2-[3-methyl-3-(2,4,5-trimethyl-3,6-dioxo-cyclohexa-1,4-dienyl)-butyrylamino]-butyrylamino}-succinamic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: Na₂S₂O₄ / diethyl ether; H₂O / 0.25 h / Ambient temperature

2: ClCOO-i-Bu, N-methylpiperidine / tetrahydrofuran

With N-methylcyclohexylamine; sodium dithionite; isobutyl chloroformate; In tetrahydrofuran; diethyl ether; water;
DOI:10.1016/S0040-4039(00)61583-6