(S)-2-((2S,3R)-2-Amino-3-hydroxy-butyrylamino)-pentanedioic acid 5-amide 1-({(S)-1-[(S)-1-({[(S)-1-((S)-1-carbamoyl-3-methylsulfanyl-propylcarbamoyl)-3-methyl-butylcarbamoyl]-methyl}-carbamoyl)-2-phenyl-ethylcarbamoyl]-2-phenyl-ethyl}-amide)

Base Information

Chemical Name:(S)-2-((2S,3R)-2-Amino-3-hydroxy-butyrylamino)-pentanedioic acid 5-amide 1-({(S)-1-[(S)-1-({[(S)-1-((S)-1-carbamoyl-3-methylsulfanyl-propylcarbamoyl)-3-methyl-butylcarbamoyl]-methyl}-carbamoyl)-2-phenyl-ethylcarbamoyl]-2-phenyl-ethyl}-amide)
CAS No.:81682-65-7
Molecular Formula:C₄₀H₅₉N₉O₉S
Molecular Weight:842.029
Hs Code.:

(S)-2-((2S,3R)-2-Amino-3-hydroxy-butyrylamino)-pentanedioic acid 5-amide 1-({(S)-1-[(S)-1-({[(S)-1-((S)-1-carbamoyl-3-methylsulfanyl-propylcarbamoyl)-3-methyl-butylcarbamoyl]-methyl}-carbamoyl)-2-phenyl-ethylcarbamoyl]-2-phenyl-ethyl}-amide)

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Chemical Property of (S)-2-((2S,3R)-2-Amino-3-hydroxy-butyrylamino)-pentanedioic acid 5-amide 1-({(S)-1-[(S)-1-({[(S)-1-((S)-1-carbamoyl-3-methylsulfanyl-propylcarbamoyl)-3-methyl-butylcarbamoyl]-methyl}-carbamoyl)-2-phenyl-ethylcarbamoyl]-2-phenyl-ethyl}-amide)

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Technology Process of (S)-2-((2S,3R)-2-Amino-3-hydroxy-butyrylamino)-pentanedioic acid 5-amide 1-({(S)-1-[(S)-1-({[(S)-1-((S)-1-carbamoyl-3-methylsulfanyl-propylcarbamoyl)-3-methyl-butylcarbamoyl]-methyl}-carbamoyl)-2-phenyl-ethylcarbamoyl]-2-phenyl-ethyl}-amide)

There total 5 articles about (S)-2-((2S,3R)-2-Amino-3-hydroxy-butyrylamino)-pentanedioic acid 5-amide 1-({(S)-1-[(S)-1-({[(S)-1-((S)-1-carbamoyl-3-methylsulfanyl-propylcarbamoyl)-3-methyl-butylcarbamoyl]-methyl}-carbamoyl)-2-phenyl-ethylcarbamoyl]-2-phenyl-ethyl}-amide) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: Boc-Thr(OBzl)-Gln-Phe-Phe-Gly-OH

: 81682-65-7
(S)-2-((2S,3R)-2-Amino-3-hydroxy-butyrylamino)-pentanedioic acid 5-amide 1-({(S)-1-[(S)-1-({[(S)-1-((S)-1-carbamoyl-3-methylsulfanyl-propylcarbamoyl)-3-methyl-butylcarbamoyl]-methyl}-carbamoyl)-2-phenyl-ethylcarbamoyl]-2-phenyl-ethyl}-amide)

Guidance literature:: Multi-step reaction with 3 steps

1: 98 percent / hydrogene / 10 percent Pd/C / dimethylformamide; H₂O

2: 55 percent / 1-hydroxybenztriazole, dicyclohexylcarbodiimide, N-methylmorpholine / dimethylformamide / 2 h, 0 deg C then 24 h, room temp.

3: 1.75N HCl / acetic acid / 1 h

With 4-methyl-morpholine; hydrogenchloride; hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium on activated charcoal; In water; acetic acid; N,N-dimethyl-formamide;

Reference yield:

: 81682-78-2
C₄₅H₆₇N₉O₁₁S

: 81682-65-7
(S)-2-((2S,3R)-2-Amino-3-hydroxy-butyrylamino)-pentanedioic acid 5-amide 1-({(S)-1-[(S)-1-({[(S)-1-((S)-1-carbamoyl-3-methylsulfanyl-propylcarbamoyl)-3-methyl-butylcarbamoyl]-methyl}-carbamoyl)-2-phenyl-ethylcarbamoyl]-2-phenyl-ethyl}-amide)

Guidance literature:: With hydrogenchloride; In acetic acid; for 1h; Yield given;

Reference yield:

: 2280-68-4
N-tert-butoxycarbonyl-L-leucyl-L-methioninamide

: 81682-65-7
(S)-2-((2S,3R)-2-Amino-3-hydroxy-butyrylamino)-pentanedioic acid 5-amide 1-({(S)-1-[(S)-1-({[(S)-1-((S)-1-carbamoyl-3-methylsulfanyl-propylcarbamoyl)-3-methyl-butylcarbamoyl]-methyl}-carbamoyl)-2-phenyl-ethylcarbamoyl]-2-phenyl-ethyl}-amide)

Guidance literature:: Multi-step reaction with 3 steps

1: 1.75 N HCl / acetic acid

2: 55 percent / 1-hydroxybenztriazole, dicyclohexylcarbodiimide, N-methylmorpholine / dimethylformamide / 2 h, 0 deg C then 24 h, room temp.

3: 1.75N HCl / acetic acid / 1 h

With 4-methyl-morpholine; hydrogenchloride; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In acetic acid; N,N-dimethyl-formamide;