methyl (41S,12R,13aR)-13a-ethyl-12- hydroxy-2,3,41,5,6,12,13,13aoctahydro- 1H-indolo[3,2,1- de]pyrido[3,2,1-ij][1,5]naphthyridine- 12-carboxylate

Base Information

• Chemical Name: methyl (41S,12R,13aR)-13a-ethyl-12- hydroxy-2,3,41,5,6,12,13,13aoctahydro- 1H-indolo[3,2,1- de]pyrido[3,2,1-ij][1,5]naphthyridine- 12-carboxylate
• CAS No.: 83508-83-2
• Molecular Formula: C₂₁H₂₆N₂O₃
• Molecular Weight: 354.449
• Mol file: 83508-83-2.mol

Synonyms:

Chemical Property of methyl (41S,12R,13aR)-13a-ethyl-12- hydroxy-2,3,41,5,6,12,13,13aoctahydro- 1H-indolo[3,2,1- de]pyrido[3,2,1-ij][1,5]naphthyridine- 12-carboxylate

Chemical Property:

• Boiling Point: 508.9±50.0 °C(Predicted)
• PKA: 12.13±0.40(Predicted)
• Density: 1.36±0.1 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: (3S,14R,16R)-VIncamine is a diastereomer of Vincamine (V314030) which is often used as a nootropic agent to combat the effects of aging, or in conjunction with other nootropics (such as piracetam) for a variety of purposes. Vincamine is a peripheral vasodilator that increases blood flow to the brain.

Technology Process of methyl (41S,12R,13aR)-13a-ethyl-12- hydroxy-2,3,41,5,6,12,13,13aoctahydro- 1H-indolo[3,2,1- de]pyrido[3,2,1-ij][1,5]naphthyridine- 12-carboxylate

There total 5 articles about methyl (41S,12R,13aR)-13a-ethyl-12- hydroxy-2,3,41,5,6,12,13,13aoctahydro- 1H-indolo[3,2,1- de]pyrido[3,2,1-ij][1,5]naphthyridine- 12-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(-)-vincadifformine (3247-10-7) → 14-hydroxy-14,15-dihydro-eburnamenine-14-carboxylic acid methyl ester (1617-90-9,2122-39-6,6835-99-0,18210-81-6,18374-18-0,18374-19-1,38990-16-8,38990-17-9,58000-63-8,70630-14-7,78341-03-4,83508-82-1,83508-83-2)

Guidance literature:

With maleic anhydride; dihydrogen peroxide; In methanol; N,N-dimethyl-formamide; at 5 ℃; for 2h;

DOI:10.3987/COM-07-11114

Reference yield:

→ (+/-)-Vincamin (1617-90-9,2122-39-6,6835-99-0,18210-81-6,18374-18-0,18374-19-1,38990-16-8,38990-17-9,58000-63-8,70630-14-7,78341-03-4,83508-82-1,83508-83-2)

Guidance literature:

14,15-Dioxo-homoeburnan, NaOCH3;

Reference yield:

→ 14-hydroxy-14,15-dihydro-eburnamenine-14-carboxylic acid methyl ester (1617-90-9,2122-39-6,6835-99-0,18210-81-6,18374-18-0,18374-19-1,38990-16-8,38990-17-9,58000-63-8,70630-14-7,78341-03-4,83508-82-1,83508-83-2)

Guidance literature:

(-)Vincadifformin*HCl, CuSO4, Sauerstoff;

upstream raw materials:

(-)-vincadifformine

Downstream raw materials:

vincamin