(6R,7R)-5,5-Dicyano-3-methyl-7-{[1-(4-nitro-phenyl)-meth-(E)-ylidene]-amino}-8-oxo-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid allyl ester

Base Information

Chemical Name:(6R,7R)-5,5-Dicyano-3-methyl-7-{[1-(4-nitro-phenyl)-meth-(E)-ylidene]-amino}-8-oxo-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid allyl ester
CAS No.:145050-22-2
Molecular Formula:C₂₁H₁₇N₅O₅
Molecular Weight:419.396
Hs Code.:

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Chemical Property of (6R,7R)-5,5-Dicyano-3-methyl-7-{[1-(4-nitro-phenyl)-meth-(E)-ylidene]-amino}-8-oxo-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid allyl ester

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Technology Process of (6R,7R)-5,5-Dicyano-3-methyl-7-{[1-(4-nitro-phenyl)-meth-(E)-ylidene]-amino}-8-oxo-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid allyl ester

There total 12 articles about (6R,7R)-5,5-Dicyano-3-methyl-7-{[1-(4-nitro-phenyl)-meth-(E)-ylidene]-amino}-8-oxo-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid allyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 74503-07-4
allyl oxalyl chloride

: 145050-22-2,145107-73-9
(6R,7S)-5,5-Dicyano-3-methyl-7-{[1-(4-nitro-phenyl)-meth-(E)-ylidene]-amino}-8-oxo-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid allyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / iPr₂NEt / CH₂Cl₂ / 0.5 h / -78 °C

2: 30 percent / P(OEt)3 / xylene / 0.33 h / Heating

With N-ethyl-N,N-diisopropylamine; triethyl phosphite; In dichloromethane; xylene;
DOI:10.1016/S0040-4039(00)60017-5

Reference yield:

: 74503-07-4
allyl oxalyl chloride

: 145050-22-2,145107-73-9
(6R,7R)-5,5-Dicyano-3-methyl-7-{[1-(4-nitro-phenyl)-meth-(E)-ylidene]-amino}-8-oxo-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid allyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / iPr₂NEt / CH₂Cl₂ / 0.5 h / -78 °C

2: 30 percent / P(OEt)3 / xylene / 0.33 h / Heating

With N-ethyl-N,N-diisopropylamine; triethyl phosphite; In dichloromethane; xylene;
DOI:10.1016/S0040-4039(00)60017-5

Reference yield:

: 145050-18-6
2-(2-methylallyl)-malononitrile

: 145050-22-2,145107-73-9
(6R,7S)-5,5-Dicyano-3-methyl-7-{[1-(4-nitro-phenyl)-meth-(E)-ylidene]-amino}-8-oxo-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid allyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 70 percent / LHMDS / tetrahydrofuran / 0.67 h / -35 °C

2: 1.) O₃, 2.) DMS / 1.) CH₂Cl₂, -45 deg C

3: 100 percent / iPr₂NEt / CH₂Cl₂ / 0.5 h / -78 °C

4: 30 percent / P(OEt)3 / xylene / 0.33 h / Heating

With 2,3-dimercapto-succinic acid; ozone; N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane; triethyl phosphite; In tetrahydrofuran; dichloromethane; xylene;
DOI:10.1016/S0040-4039(00)60017-5